CHIMERIC ANTIGEN RECEPTOR FOR CHRONIC LYMPHOCYTIC LEUKEMIA - A REVIEW
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 1
Abstract
Chronic lymphocytic leukemia cancer is a deadly one which affects the bone marrow from making it to produce more amounts of white blood cells in the humans. This disease can be treated either by radiation therapy, bone marrow transplantation, chemotherapy, or immunotherapy. In radiation therapy, the ionizing radiation is used toward the tumor cells, but the main drawback is the radiation may affect the normal cells as well. To overcome this drawback, immunotherapy chimeric antigen receptor (CAR) is used. These CAR cells will target only the antigen of the tumor cells and not damage the normal cells in the body. In this therapy, the T-cells are taken either from the patients or a healthy donor and are engineered to express the CARs which are called as CAR-T-cells. When these CAR-T-cells come in contact with the antigen present on the surface of the tumor cells, they will get activated and become toxic to the tumor cells. This new class of therapy is having a great prospect in cancer immunotherapy.
Authors and Affiliations
Kiruthiga Raghunathan, Brindha Devi P
Keywords
Related Articles
- EP ID EP607095
- DOI 10.22159/ajpcr.2019.v12i1.29642
- Views 118
- Downloads 0
PROTECTIVE EFFECT OF ROTENONE AGAINST LIPOPOLYSACCHARIDE AND D-GALACTOSAMINE-INDUCED HEMATOTOXICITY
Objective: The aim of the present study was to investigate the protective efficacy of rotenone against lipopolysaccharide (LPS) and D-galactosamine (D-GalN)-induced altered hematology. Methods: Hematotoxicity was induce...
THE PROTECTIVE EFFECTS OF ECHINOPS HETEROPHYLLUS AQUEOUS EXTRACT AGAINST METHOTREXATE-INDUCED HEPATOTOXICITY IN RABBITS
Objective: The aim of this study was to investigate antioxidant and hepatoprotective properties of Iraqi Echinops heterophyllus aqueous crude extract and its flavonoid fraction against methotrexate (MTX)-induced hepatoto...
IN VITRO AND IN VIVO STUDIES OF ANTIHYPERURICEMIC AND ANTIOXIDANT ACTIVITY FROM BULBS OF BAWANG TIWAI (ELEUTHERINE PALMIFOLIA (L.) MERR.) FROM INDONESIA
Objectives: This study would like to investigate the in vitro antioxidant activity through 2,2-diphenyl-1-picrylhydrazyl assay and in vitro xanthine oxidase activity of the bulbs. This study performs in vivo assays to st...
FORMULATION AND EVALUATION OF MODIFIED ORAL CHRONOTROPIC DRUG DELIVERY SYSTEMS OF TRAMADOL HYDROCHLORIDE FOR RHEUMATOID ARTHRITIS PAIN
Objective: The main aim was to develop a modified oral chronotropic system for timed release tramadol hydrochloride (tramadol HCl). Biological rhythms are highly organized for all functions of the human body both in heal...
CONVENTIONAL AND RECENT DIAGNOSTIC AIDS IN TUBERCULOUS LYMPHADENITIS: A BRIEF OVERVIEW
One of the most common form of extra-pulmonary tuberculosis is peripheral tuberculous lymphadenitis and accounts for 20-40% of the cases. Tuberculous lymphadenitis has a gender and age predilection (usually seen in young...