Chromogenic Spectrophotometric Estimation of Brivaracetam in Bulk drug & its Formulation with Folin Ciocalteu reagent
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2017, Vol 7, Issue 12
Abstract
Simple, precise, economic & less time consuming visible spectroscopic method for Brivaracetam was developed by using Folin Ciocalteu Reagent (FCR) in the presence of base. The absorption maximum of the chromogen was found to be 475 nm. The developed method was obeying Beer Lambert’s law in the range of 2-20 µg/ml concentration. The method has also been statistically evaluated & the results were within the limits. Molar absorptivity, Sand ell’s sensitivity a& Correlation –co-efficient were found to be 1.528 x 103 , 0.109 and 0.998 respectively & the method is free from the interferences of other additives present in the formulation.
Authors and Affiliations
Imam Pasha. S, Murali Balaram Varanasi, Ibrahim Mohammed
Keywords
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