Anti Inflammatory Effect of Azadirachta Indica (Neem) In Albino Rats-An Experimental Study
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 1
Abstract
[b] Introduction:[/b] Inflammation is body’s attempt at self protection characterized by five cardinal signs; it may be acute or chronic. NSAID(non steroidal anti-inflammatory drugs are the commonly used to reduce the inflammation. traditional Indian system of medicine mentions neem(Azadirachta Indica)to have many medicinal properties. so the present study was carried out to access the anti-inflammatory effect of neem. [b]Materials and methods:[/b] Albino rats were used; they were divided into three groups. Control group treated with normal saline, standard treated with Indomethacin and test drug used was neem oil. For acute inflammation; Carregennan induced rat paw edema inhibition method and for sub acute inflammation: cotton pellet granulation method. Ulcer index of Indomethacin and test compound were also studied. [b]Results:[/b] it is found that neem oil showed significant anti-inflammatory effect in both acute as well as chronic inflammation, it was also found to have low ulcerogenic potential compared to Indomethacin, hence can be safely used as a potent anti-inflammatory agent
Authors and Affiliations
Dr. Jagadeesh. K, , Dr. Srinivas. K
Keywords
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