Chronic Graft-Versus Host Disease - Single Center Experience
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2008, Vol 1, Issue 1
Abstract
Background. With the increasing number of patients surviving peritransplant complications of stem-cell transplantation (SCT), the incidence of chronic Graft Versus Host Disease (cGVHD) has increased too. cGVHD now develops in approximately 30-50% of patients undergoing SCT. Risk factors associated with the development of cGVHD are: previous acuteGVHD (aGVHD), prior cytomegalovirus infection, use of a matched unrelated donor and combination of a male recipient with a female donor. Not all patients who develop aGVHD progress to cGVHD. The latter may occur de novo. Aim. To describe clinical and patohistological findings and influence of cGVHD on survival in allogeneic stem cell recipients. Material and methods. During 7 years period we have treated 40 patients with allogeneic SCT from HLA identical sibling. aGVHD prophylaxis comprised Seattle protocol. Results. 12 patients (6 males, 6 females; mean age: 34,5) developed cGVHD (7 de novo). Distribution according to diagnosis: Acute Myeloid Leukemia (n=8), Chronic Myeloid Leukemia (n=3), Primary myelofibrosis (n=1). Six of them had limited disease, and 6 had extensive. Treatment comprised: corticosteroids + CsA (6), Mophetyl mycophenolate (4), Tacrolimus (2), Photochemiotherapy (3). 10 (83%) patients are alive; 2 (17%) died. Conclusion. Despite advances in histocompatibility matching and immunosuppressive drugs, GVHD has continued to be a common and often lethal complication of SCT.
Authors and Affiliations
Zlate Stojanoski| Hematology Clinic, Medical Faculty, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Svetlana Krstevska-Balkanov| Institute for Pathology, Medical Faculty, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Georgi Gocev| Dermatology Clinic, Medical Faculty, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Sonja GenadievaStavrik| Hematology Clinic, Medical Faculty, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Lidija Cevreska| Hematology Clinic, Medical Faculty, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Borche Georgievski| Hematology Clinic, Medical Faculty, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia
Keywords
Related Articles
- EP ID EP8584
- DOI 10.3889/MJMS.1857-5773.2008.0006
- Views 467
- Downloads 26
A Randomized Double Blind Clinical Study on the Efficacy of Low Level Laser Therapy in Reducing Pain After Simple Third Molar Extraction
Aim. The aim of this clinical study was to test the efficacy of Low level laser therapy (LLLT) in controlling post-operative pain after simple third molar extraction in a double blind, randomized placebo control study....
The Attitudes of Students - Future Health Professionals Regarding Tobacco Usage
Introduction: Smoking is considered as a lading cause of death it can be avoided of course. But, it seems paradox because in spite of numerous information of harmful effects due smoking, received through educational pr...
The Awareness of Medical Students in Nigerian Universities about the Use of Plastinated Specimens for Anatomical Studies
Over the past decade, the role of anatomical teaching in the undergraduate medical curriculum has changed considerably. At some medical schools, active dissection of cadaveric specimens is gradually being replaced by p...
A Novel Mutation in the GJB2 (Connexin 26) Gene in Egyptian Children with Non-syndromic Sensorineural Hearing Loss
This study aimed to investigate the frequency of any novel gene mutations, in human GJB2 gene among Egyptians with familial sensorineural non-syndromic hearing impairment. PCR amplifying the entire coding region of GJB...
Lumbar Spinal Stenosis in Older Adults - Gender Differences
Background. Spinal stenosis usually occurs in older adults. The treatment of this condition is with varying success It is necessary to assess the risk and the expected benefits of the treatment (surgical or not surgica...