CHRONOTHERAPY FOR NOCTURNAL ASTHAMA
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 3
Abstract
Chronotherapeutic drug delivery system is useful in the treatment of disease, in which drug availability is timed to match rhythm of disease, in order to optimize therapeutic effect and minimize side effect. Nocturnal asthma is defined as any sleep related worsening of reversible airway disease. Approximately 80 percent of severe asthmatic attacks occur between midnight and 8 a.m. Nocturnal asthma is associated with critical symptoms and urgent need for proper medications. The onset of nocturnal asthmatic attacks is rare in the first part of night, 80% of asthmatic attacks occur between midnight and 8 a.m., and deaths from asthma are more common during these hours. In a study of asthma mortality, 79% of the patients who died had a disturbed sleep before the death. In a survey of almost 8000 patients with varying degrees of asthma found that approximately - 75% of asthmatics attacks happened once a week with symptoms, 64 % three times a week, and 39 % every night. Nocturnal asthma is currently controlled by taking either a long-acting β2 agonists like salmetrol inhalers, sustained release theophylline. All the current sustained release formulation has a shortcoming of inability to maintain high blood levels for that long period. This may lead to leaving the patient unprotected against the worse events of nocturnal asthma. Thus, a smart drug delivery that is administrated before sleep and maintains high blood levels for longer period (from midnight to 8 am in the morning) could be very much beneficial for proper management of nocturnal asthma.
Authors and Affiliations
Papola Vibhooti Rajan G, Bisht Seema, Dr. Kothiyal Preeti
Keywords
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