Cigarette Smoking Has no Impact on the Effect of Radioiodine Therapy in Patients with Graves Disease
Journal Title: Acta Facultatis Medicae Naissensis - Year 2015, Vol 32, Issue 1
Abstract
Presently, there is very little data on the impact of nicotine and other components of tobacco smoking on the outcome of radioiodine therapy (RIT) in Graves’ disease (GD). Thus, this study was aimed to analyze a possible impact of cigarette smoking on the effect of radioiodine therapy in the patients with Graves’ disease. The study included 31 patients (16 smokers and 15 non-smokers) with GD, aged from 22 to 73 years, who were treated with a single dose of iodine-131 sodium iodide (131I-NaI) and subjected to a 12-month follow-up, thereafter. Patients were treated with antithyroid drugs (ATDs) before RIT and described very intense stressful events occurring prior to diagnosing Graves’ hyperthyroidism. A successful response to RIT was defined as euthyroidism and subclinical or clinical hypothyroidism, while an unsuccessful response was defined as persistent hyperthyroidism. Comparison of age (47.4±9.41 vs. 49.5±13.8 years, p=0.628) at the time of RIT, applied activity of 131I-NaI (372±78.4 vs. 363±43.7 MBq, p=0.675), and duration of ATDs therapy (3.47±3.33 vs. 4.94±5.62 years, p=0.387) between smokers and non-smokers showed no significant difference. The cumulative incidence of successful response to therapy in smokers and non-smokers was 31.2 vs. 46.7% (p<0.05), 50.0 vs. 60.0% (p>0.05), 56.2 vs. 60.0% (p>0.05), and 56.2 vs. 66.7% (p>0.05) after 3, 6, 9 and 12 months, respectively. The results showed that cigarette smoking has no impact on the effect of radioiodine therapy after twelve-month period in patients who had experienced stressful events before the occurrence of Graves’ disease. However, patients with smoking habits achieved successful response later than non-smokers.
Authors and Affiliations
Vladan Sekulić, Milena Rajić, Marina Vlajković, Slobodan Ilić, Miloš Stević, Ivana Mišić, Milan Božinović
Keywords
Related Articles
- EP ID EP153138
- DOI 10.1515/afmnai-2015-0007
- Views 93
- Downloads 0
How Likely Is It for a Nurse Student to Become a Competent Nurse? A Protocol for Scale Development and Validation Using a Mixed Methods Study
The aim of the paper was to develop and validate a scale for estimating the likelihood of a nurse student to become a competent nurse. Admitting students to nursing schools without assessing their personal characterist...
TRANSPLANTACIJA UMBILIKALNIH MATIČNIH ĆELIJA HEMATOPOEZE KOD ODRASLIH BOLESNIKA SA MALIGNIM HEMOPATIJAMA
Transplantacija matičnih ćelija hematopoeze iz umbilikalne krvi se u proteklim godinama pokazala kao uspešna alternativna metoda lečenja odraslih bolesnika sa malignim i nemalignim hematološkim bolestima, koji nisu imali...
MARGINALNA PUKOTINA I OŠTEĆENJE GLEĐI OKO ADHEZIVNIH RESTAURACIJA ZUBA (in vitro SEM ispitivanje)
Postoje tri adhezivna restaurativna sistema: nagrizanje uz ispiranje, “etch and rinse”, samo nagrizanje “self etch” i glas jonomer sistem. Marginalna pukotina i oštećenje marginalne gleđi oko kompozitnih i glas jonomer r...
Analiza faktora udruženih sa smtrnim ishodom kod pacijenata sa teškim nekrotičnim akutnim pankreatitisom
Cilj ove studije bio je da utvrdi faktore u vezi sa inicijalnom terapijom koji mogu doprineti smrtnom ishodu kod bolesnika sa teškim nekrotičnim akutnim pankreatitisom i da analiziraju njihov klinički značaj, kao i moguć...
NOVI LEKOVI U TERAPIJI OSTEOPOROZE: pregled 2. i 3. faze kliničkih istraživanja
Osteoporoza je hronična bolest koja je sve više zastupljena i to pretežno kod osoba ženskog pola. Postoje dokazi da bisfosfonati, selektivni modulatori estrogenskih receptora, denosumab, teriparatid i stroncijum ranelat...