Clinical and Functional Outcomes of Sensitizer-Induced Asthma in Bakers and Cotton Workers after Removal from Exposure
Journal Title: Archives of Pulmonology and Respiratory Care - Year 2016, Vol 2, Issue 1
Abstract
Introduction: Sensitizer-induced occupational asthma (OA) has significant health and socioeconomic outcomes in affected subjects. Objective: To evaluate clinical and functional outcomes of sensitizer-induced OA in bakers and cotton workers three to five years after cessation of exposure to the offending workplace agent. Methods: We studied 16 patients with sensitizer-induced OA (10 bakers and 6 textile workers), eight males and eight females, aged 32 to 48 years. All study subjects completed a questionnaire and underwent spirometric measurements and metacholine challenge, in the same manner as at the time of diagnosis. The findings obtained were compared with findings registered at the time of diagnosis. Results: We found significantly lower prevalence of patients with respiratory symptoms in the previous 12 months after the mentioned period of removal from exposure than their prevalence at the time of diagnosis (100% vs. 68.7%; P = 0.014). In regard to nasal symptoms, their prevalence at the time of the study was lower than at the time of diagnosis but statistical significance was not reached (62.5% vs. 37.5%; P = 0.107). The values of spirometric parameters at the time of the study were similar to their values at the time of diagnosis. The level of the non-specific bronchial hyper responsiveness (NSBHR) at the time of the study was improved in all study subjects. The mean value of the provocative concentration 20 (PC20) at the time of the study was significantly higher than its mean value registered at the time of diagnosis (2.9 vs. 2.1; P = 0.032). However, none subject normalized his/her NSBHR. Conclusions: Our findings indicate resolution of the respiratory and nasal symptoms in a part of the study subjects. In addition, all study subjects are left with their NSBHR, although all of them improve.
Authors and Affiliations
Minov Jordan B, Bislimovska Jovanka Karadzinska, Tutkun Engin, Vasilevska Kristin, Stoleski Saso, D Mijakoski
Keywords
Related Articles
- EP ID EP340386
- DOI 10.17352/aprc.000007
- Views 98
- Downloads 0
Timing and Efficacy of VATS Debridement in the Treatment of Parapneumonic Empyema
Objectives: Empyema thoracis is a common thoracic disease seen in both developing and developed countries. Despite modern management techniques, this condition is still associated with significant morbidity and mortality...
Asthma, Anxiety and Depression are they walking together? Cross-Sectional Descriptive Study
Background/Objectives: The association between asthma and mental health disorders is well known, both anxiety and depression being the most common ones. The aim is to determine the proportion of anxiety and/or depression...
Impact of Calorie Intakes on the Risk of Bronchopulmonary Dysplasia in Extremely Preterm Infants
Aim: To examine whether caloric intake during the first week of age influences the risk of Bronchopulmonary Dysplasia (BPD) in extremely preterm infants. Methods: In this retrospective cohort study, all infants born with...
Spontaneous Haemomediastinum and Fatal Haemoperitoneum in woman with Vascular Ehlers-Danlos Syndrome
Vascular Ehlers-Danlos Syndrome (EDS) presents with fragility of blood vessels, with high incidence of fatal hemorrhages in middle-age adults. We present a 38-year old female with vascular EDS presented to the emergency...
Travelling to High Altitudes Could be Thrombogenetic!
People ascending to high altitude regions are at risk for a variety of health problems, commonly including acute mountain sickness (AMS), high-altitude cerebral oedema (HACE) and high-altitude pulmonary oedema (HAPE) etc...