Clinical and Haematological Pattern of Chronic Lymphocytic Leukaemia in Sudanese Patients
Journal Title: International Blood Research & Reviews - Year 2017, Vol 7, Issue 1
Abstract
Aims: Chronic lymphocytic leukemia is the most frequent adult leukemia in Western countries accounting for 25 to 30% of all leukemic patients. The clinical and haematological features vary from patient to patient. The aim of this study is to describe the clinical presentation of chronic lymphocytic leukemia, to evaluate haematological patterns of the disease in the peripheral blood and bone marrow and to correlate them with the clinical stage of the disease. Study Design: This is a retrospective descriptive study. Place and Duration: Radio Isotope Centre Khartoum (RICK), haematology laboratory during the period of January 2010 to December 2011. Methodology: The data were collected at the haematology laboratory from patients’ records as well as from a special questionnaire designed for this study. Clinical data, complete blood count, bone marrow examination and immunophenotyping results were used. Results: Out of 98 cases studied 69 (70.4%) were males and 29 (29.6%) were females. Sixteen patients (16.3%) were less than 50 years old (young patients) and 82 (83.7%) were more than 50 years of age (elderly patients). 49.1% of the patients were from western Sudan. Eight patients (8.2%) were asymptomatic. Absolute lymphocyte count above 5× 109/L had significant association with diffuse pattern of infiltration (P value=0.035) and was not significantly associated with advanced Rai stage (stage III 32.6%, Rai stage IV 22.8%) (P value=0.710). Conclusion: Clinical and haematological pattern of chronic lymphocytic leukaemia in Sudanese patients has comparable results with previous studies in other parts of the world. Most of the patients were elderly male, from western Sudan presented with nonspecific symptoms, generalized lymphadenopathy and leukocytosis. The majority of patients presented in advanced stage at the diagnosis.
Authors and Affiliations
Rasha Abd Elgleel Mohammed Ahmed, Ihsan Mohammed Osman
Keywords
Related Articles
- EP ID EP306671
- DOI 10.9734/IBRR/2017/31359
- Views 117
- Downloads 0
In vitro Anti-erythrocyte Sickling Effect of Lunularic Acid of Natural Origin
Aims: To evaluate the antisickling activity of lunularic acid. Study Design: Biological experiment in vitro (Emmet test), evaluation of cell morphological parameters such as radius, perimeter and surface. Place and Durat...
The Prevalence of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in Students of Sultan Abdurrahaman School of Health Technology Gwadabawa, Sokoto, North-Western Nigeria
Background: The aim of this study was to determine the prevalence of the deficiency of Glucose-6-phosphate 10 dehydrogenase (G6PD) activity among students of Sultan Abdurrahaman School of Health Technology Gwadabawa, Sok...
Lipid Profile as a Marker of Pre-stage Cancer and Oral Cancer in Tobacco Users
Aim: To investigate the serum lipid profile in conventional smokers, reverse smokers and tobacco chewers and smokers and chewers associated with precancer and oral cancer. Study Design: A cross sectional longitudinal stu...
Iron Status and Red Cell Parameters in Pregnant and Non-pregnant Adolescents in Côte d’Ivoire (West Africa)
Aims: The objective of this study was to evaluate iron metabolism and compare iron stores between pregnant and non-pregnant adolescents in Côte d’Ivoire. Place and Duration of Study: The study was undertaken with 187 vo...
ABO & Rh (D) Phenotypes and Alleles in the Patients with Parkinson’s Disease among the North Indian Population
Aim: Recent studies have pointed the association of blood groups with cognitive impairment and dementia. This study was planned to find the frequencies of ABO, Rh (D) alleles and examine the effect of their phenotype in...