Outpatient Management of Acute Leukemia: A Systematic Review and Meta Analysis
Journal Title: International Blood Research & Reviews - Year 2016, Vol 6, Issue 3
Abstract
Background/Aim: Outpatient chemotherapy administration for solid tumors is a commonly accepted practice given its advantage of easy and safe drug administration, ability to value the patient’s wish to avoid hospitalization and decreased expenses compared to inpatient care. However, this practice is not commonly extended to patients with acute leukemia. The aim of this study was to compile the evidence about outpatient and early discharge of acute leukemia patients and its effects on the outcome. Methods: A systematic review was done using MEDLINE, EMBASE and Cochrane Library databases. Both retrospective and prospective cohort studies as well as clinical trials for acute leukemia were included. Results: Twenty one studies were included in this systematic review: Ten retrospective studies, 10 prospective studies and one non-randomized phase 2 trial. Most of the included studies reported that outpatient chemotherapy is feasible, safe, and resulted in decreased hospitalization days. Conclusion: Studies reporting on outpatient and early discharge of acute leukemia are largely observational and highly heterogeneous. A trend towards a reduced incidence of septicemia was observed with early discharge. The effect of other clinical outcome measures was unclear. Reporting on social and economic impact is suboptimal.
Authors and Affiliations
O. Elemam, S. Elmorsy, A. Shanqeeti, D. Abdelmoety
Keywords
Related Articles
- EP ID EP242741
- DOI 10.9734/IBRR/2016/29025
- Views 107
- Downloads 0
In vitro Study of Antioxidant and Anticoagulant Activities of Ethanol Extract of Pandanus tectorius Leaves
Pandanus tectorius of the family Pandanaceae is a medicinal plant that grows in Nigeria. The Pandanus tectorius extract was tested for; its acute toxicity using mice and, its antioxidant activities (using DPPH spectromet...
Epidemiological and Biological Parameters of Monoclonal Plasma Cell Dyscrasias in Thirty One Patients Consulting a Moroccan Pasteur Institute
Aims: To describe epidemiological and biological features of patients with monoclonal plasma cell dyscrasias. The patients were seen at the Moroccan Pasteur Institute in Casablanca during a period of two years and four m...
Relationships between Blood Transfusion, Severity of Injury and Outcome of Severely Injured Patients Admitted to a Trauma Intensive Care Unit in Nigeria: An Observational Study
Background: Anaemia is common in critically ill trauma patients admitted into the Intensive Care Unit. The aetiology of the anaemia in trauma patients is often multi-factorial, usually resulting from the trauma event, fr...
Changes in Packed Cell Volume and Some Biochemical Parameters of Adult Females during Pregnancy in North-West Nigeria
Background: Pregnancy is associated with changes in woman’s renal function, carbohydrate and protein metabolism and particularly hormonal pattern. The objective of this study was to determine the values of packed cell vo...
Calotropis procera Extract Halts Plasmodium falciparum Transgression Through Red Blood Cell (RBC) Membrane
Aim: To evaluate the potential of Calotropis procera extracts in erythrocyte membrane stabilization with special emphasis on Plasmodium falciparum entry into RBCs. Place and Duration of Study: Department of Zoology, BMT...