Clinical and Histopathological Analysis of Kidney Biopsies at Tertiary Care Hospital
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 6
Abstract
Introduction: Kidney biopsy is valuable test with diagnostic & prognostic value and plays an important role in planning definitive management. Methods: All biopsies were examined with Light Microscopy and Immunofluroscene & EM was performed as and when indicated. We recorded name, age, sex, indication for renal biopsy, histopathological diagnosis and laboratory investigations. Total of 117 biopsies were done during period of January 2016 to October 2017. 87 of 117 biopsies analysed, others were excluded (Allograft biopsies and incomplete records). Results: Mean age was 30.80+13.68 years with 44 (50.57%) males and 43 (49.43%) females. Most common indication was nephrotic syndrome in 32 (36.78%), followed by Systemic lupus erythematosus with lupus nephritis in 20 (22.98%), 13 (14.94%) with Acute kidney injury, 10 (11.49%) Rapidly Progressive Renal Failure, 4 (4.59%) patients were clinically chronic kidney disease with normal size kidneys. Most common primary glomerular disease (PGD) seen in males and females was membranous nephropathy (20.45% and 16.27% respectively). Most common secondary glomerular disease (SGD) in males was amyloidosis (9.09%), while in females most common was Lupus Nephritis (44.18%).Most common PGD seen in age < 20 years was MCD (27.27%), in 21 -40 years was membranous nephropathy (19.14%), in 41 – 60 years was membranous (33.33%) and > 60 years was MPGN (33.33%). Most common SGD in age < 20 years was lupus nephritis (22.72%). Majority of males 18 (20.69%) presented as nephrotic syndrome (p=0.0001). Most patients 9 (10.34%) were hypertensive with mean creatinine value 7.06±6.17 mg/dl was seen in Rapidly Progressive Renal Failure (p=0.0001). Conclusion: A wide variation of major histological groups in the PGD has been observed. The most common PGD is MN while most common SGD documented is LN. The changing incidence & pattern is contributed by an increased referral due to increased awareness & use of IF & EM.
Authors and Affiliations
Kalpana S. Mehta, Pradip Saruk, Gajanan Pilgulwar, Saurabh Lande, Vikas Kavishwar
Keywords
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- EP ID EP532377
- DOI 10.21276/ijmrp.2018.4.6.003
- Views 101
- Downloads 0
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