Evaluation of Biochemical, Haematological Parameters and Noninvasive Prognostic Scores in Alcoholic Liver Disease with and without Complications
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 6
Abstract
Background: Chronic and excessive alcohol ingestion is one of the major causes of liver disease in the industrialized nations. The spectrum of pathology of alcoholic liver injury ranges from fatty liver to alcoholic hepatitis and cirrhosis. Fatty liver is present in over 90% of binge and chronic drinkers and 10 to 20 % of alcoholics develop alcoholic hepatitis. The mortality of patients with alcoholic hepatitis concurrent with cirrhosis is nearly 60% at 4 years. Various risk factors implicated in alcoholic liver disease include quantity and duration of alcohol intake, type of alcohol consumption and drinking pattern, gender, co-existent HCV infection, gene polymorphism and nutritional factors such as malnutrition/obesity. Aims and Objective: To identify the role of biochemical, haematological parameters and noninvasive prognostic scores in alcoholic liver disease with or without complications. Materials and Methods: In this study, sixty alcoholic patients with (n=32) or without (n=28) radiologic and/or clinical evidence of cirrhosis were, retrospectively evaluated to identify the role of various biochemical, haematological parameters and noninvasive prognostic scores. Results: Patients having higher values of total bilirubin (≥1.9), AST ALT ratio (≥2.3) and Lower value of albumin (<2.9) shown to have the higher risk of complications (ORs are 7.5, 5.0 and 7.5 respectively) developed in alcoholic liver disease. Similarly lower value of Hb, and higher values of TLC, MCV, PT, INR, BCDS and Maddrey’s DF shown to have higher risk of complications among the alcoholic liver disease. Multiple regression analysis revealed that the higher values of MCV (≥96.2), TLC (≥10.4) and MDR (≥24.2) are independently positively associated with the complications (ORs are 5.5, 7.6 and 29.3 respectively) developed in ALD. Conclusion: Higher values of MCV, TLC and Maddrey’s DF are playing their independent role of positive association with the complications developed in the ALD. Early evaluation and management of these easily available parameters and non- invasive scoring system may be more appropriate in prevention of development of complications among ALD cases.
Authors and Affiliations
Rajlaxmi Sarangi, Sarojini Raman, Somanath Padhi, Bhaskar Thakur
Keywords
Related Articles
- EP ID EP533090
- DOI 10.21276/ijmrp.2018.4.6.025
- Views 79
- Downloads 0
Minimally Differentiated Acute Myeloid Leukemia (FAB M0) in a Child with Down Syndrome: A Case Report
Children with Down syndrome (DS) have 10-100 fold increased risk of leukemia. >90% cases present with morphology and immunophenotype characteristic of acute megakaryoblastic leukemia (FAB M7). Other AML FAB described in...
A Retro-Prospective Study of Histopathological Findings in Isolated Left Sided Hepatic Resections in Cases of Isolated Left Sided Hepatolithiasis
Objective: To study detailed preoperative anatomy of left hepatobiliary system in cases of isolated left sided hapatolithiasis, appropriate surgical management and histopathology findings in isolated left hepatic resecti...
Endoscopic Management of Large Distal Ureteric Stones: A Case Series
Ureteric stones are a significant cause of patient morbidity and urological emergency depart visits. Management of stones depends on multiple factors related to clinical presentation, stone size, location and composition...
The Prevalence of Mandibular Third Molar Angulation in Patients Who Attended Arar Specialist Dental Centre: Panoramic Survey
Aims: This study was carried out to investigate about the prevalence of mandibular third molar angulations and which specific type of angulation is more prevalent and the classification of impaction if present according...
Clinical and Histopathological Analysis of Kidney Biopsies at Tertiary Care Hospital
Introduction: Kidney biopsy is valuable test with diagnostic & prognostic value and plays an important role in planning definitive management. Methods: All biopsies were examined with Light Microscopy and Immunofluroscen...