CLINICAL AND IMMUNOLOGICAL FEATURES OF PATIENTS WITH CHD ASSOCIATED WITH TNF-A
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 11
Abstract
The study included 101 patients with coronary heart disease aged from 34 to 76 years (56.9 ± 0.9), of them 64.4% were men and 35.6% - women. We have shown the role of TNF-α gene (-308G> A) in the development of CHD-allele A, the A/G and A/A genotypes are characterized as risky variants in the development of unstable (progressive) stenocardia in the Uzbek population. In the group of unstable stenocardia with genotype profile A/G+A/A of TNF-α gene (-308G> A), the levels of TNF-α, IL-6, IL-18, CRP and fibrinogen were reliably higher in comparison with SS and control groups. Despite the fact that we have shown the role of TNF-α (-308G> A) in the development of CHD in the Uzbek population, further study of this SNP on much more material is necessary, in connection with the already known risk factors to establish its potential causal relationship.
Authors and Affiliations
Dr. Hegay T. R.
Keywords
Related Articles
- EP ID EP631125
- DOI -
- Views 171
- Downloads 0
EVALUATION OF SELF MEDICATION TRENDS AMONG PHARMACY AND MEDICAL STUDENTS
Self medication is common practice worldwide and it leads to irrational use of drugs among society. This cross-sectional study was conducted to evaluate the practice of self medication and different factors linked with t...
PROTEASE: AN ENZYME WITH MUTIPLE INDUSTRIAL APPLICATIONS (REVIEW)
Proteolytic enzymes are found in all kinds of organisms‟ i.e viruses to animals. These peptidases are included in vast group of the enzymes used in the bio industry with wide applications. They play vital part in the ind...
PREVALENCE OF MALARIA INFECTION AMONG VULNERABLE GROUPS IN WUSHISHI LOCAL GOVERNMENT AREA OF NIGER STATE, NIGERIA
Malarial is a chronic endemic life treating parasitic disease that obstructs social and economic development of underdeveloped counties like Nigeria. It is caused by protozoan of genus plasmodium, which is transmitted by...
EFFECT OF BETAMETHASONE ADMINISTRATION ON SKELETAL MUSCLES OF PREGNANT RATS AND THE AMELIORATIVE ROLE OF CURCUMIN
Using the skeletal muscle as a target organ, the present study involved two integrated aspects. The first aspect has dealt with investigating the possible toxic side effects of maternal exposure to one of the glucocortic...
CAUDAL VERSUS INTRAVENOUS KETAMINE FOR SUPPLEMENTATION OF ANALGESIA IN PEDIATRICS UNDERGOING HYPOSPADIAS REPAIR: A COMPARATIVE STUDY
Background: Different additives have been reported to prolong the duration of caudal anesthesia in pediatrics. Although these drugs successfully increased the duration of the block. Ketamine has been found to effectively...