Clinical and neurological peculiarities and neuroaminoacids levels in patients with somatogenic typical prosopalgias
Journal Title: Український неврологічний журнал - Year 2018, Vol 0, Issue 2
Abstract
Objective — to investigated the levels of neuroaminoacids and asparatus g‑aminobutyric acid in blood serum of patients with typical prosopalgias, and to determine neuroaminoacids and asparatus g‑aminobutyric acid influence on neurological manifestations occurrence and pain syndrome intensity. Methods and subjects. We examined 68 patients with somatogenic typical prosopalgia, among patients there were 32 women (47.06 %) and 36 men (52.94 %), age range 28 — 53 years (mean age 33.57 years). The patients were treated in State Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine and they were given basic treatment with pain killers and vascular medications in standard therapeutic dosage. 30 healthy patients (15 women and 15 men) aged 26 — 35 years (mean age 25.50 — 33) comprised a control group. Neuroaminoacids and asparatus g‑aminobutyric acid level in blood serum was determined with spectrophotometric method in order to evaluate their pathogenic influence on the pain syndrome formation and intensity. Results. It was shown that patients with typical prosopalgia and with the most severe pain syndrome (16.2 %) presented with the most significant changes of neuroaminoacids data: high level of glutamate (226.88 mkmol/l vs controls 112.75 mkmol/l) and decreased level of braking neuroaminoacids, particular, g‑aminobutyric acid compared (2.26 mkmol/l vs controls 6.72 mkmol/l) to controls and to other patient groups. Conclusions. Somatogenic typical prosopalgia, accompanied by the pain syndrome, was associated with vegetative and neurological disorders, and very severe neuroaminoacids dysbalance which was in direct ratio with the pain syndrome stage of intensity, that may play an important role in the disease pathogenesis and formation of the clinical picture peculiarities. It should be taken into consideration during diagnostic process and choosing future treatment regime.
Authors and Affiliations
M. F. Posokhov, Ye. V. Lekomtseva
Keywords
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- EP ID EP421297
- DOI 10.30978/UNZ2018258
- Views 79
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