Clinical and paraclinical corellations in acute poissoning <br /> with phenobarbital
Journal Title: Terapeutica, Farmacologie si Toxicologie Clinica - Year 2008, Vol 12, Issue 3
Abstract
[b]Introduction:[/b] The acute intoxication with barbiturates, still widely used in medical practice, is a redoubtable matter, especially when long acting compounds are involved; because they have a long half time, slowly accumulate at the tissue level and lead to severe poisoning which require promptly intensive care measures. [b]Case report:[/b] male patient 34 years old with a history of epilepsy and postencephalytic paralysis was admitted in the Toxicology Department 24 hours after the ingestion of a barbiturate overdose. The clinical state was very severe and required complex intensive care therapy. Daily measurements of plasmatic Phenobarbital levels settled a direct correlation between the positive outcome trend and decreasing barbiturates values. [b]Conclusion:[/b] The active screening of the plasmatic phenobarbital levels is very useful especially when it comes to decide if more aggressive therapeutic measures are necessary.
Authors and Affiliations
Ruxandra Avram, Gina Caragea, M. Ionică, R. Macovei
Keywords
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