Clinical and paraclinical correlations in metformin treatment
Journal Title: Medicine in Evolution - Year 2017, Vol 0, Issue 4
Abstract
Aims: Determining the degree of risk in patients with type 2 diabetes, with antidiabetic therapy, respectively with Metformin, with associated diseases. Type of study: Retrospective study of patients with diabetes mellitus and anemia in metformin therapy. Location: Arad County Clinical Emergency Hospital - Hematology Section Study participants: 351 patients (aged 18-75 years), type 2 diabetes (termed Lot DZ) admitted to the Arad Hematology Clinic from 2013 to 2015, with duration of diabetes mellitus about 1-15 years. Methods: Patients admitted to the hematology department with anemia diagnosis (feripriva, biermer, normocytar, and other anemias) were evaluated, who also received metformin treatment. We associate the study with age, sex, consumption of toxic substances, associated diseases, type of anemia and metformin treatment that the patient follows. Results: Women (61.15%, 60.53% and 57.14% respectively) predominate in the study group, the women / men ratio being 1.6: 1, 1.5: 1 and 1.3: 1 respectively; there are no significant differences between the three groups in terms of gender distribution (p = 0.445), age (p = 0.943) (mean age 54.63 years in the Metformin group, 54.95 years in the group without Metformin and 56.65 years in the group with diabetic insulinonecites). In the three subgroups, the most common conditions were cardiovascular (61.87%, 64.91% and 56.12%, respectively). Other disorders include osteoarticular disorders, thyroid disorders and psychiatric disorders (especially low or medium intensity depression). Unbalanced / very unbalanced metabolic balance was encountered particularly in patients with respiratory diseases (31.03%), cardiovascular (26.51%) and hepatic (21.95%). Conclusions: Management of type 2 diabetes mellitus (DZ2) requires aggressive treatment to achieve the proposed glycemic and cardiovascular goals and to reduce the incidence of risk factors. Metformin, an old and widely accepted first-line agent, stands out not only for its anti-hyperglycaemic properties, but also for its effects outside glycemic control, such as improving endothelial dysfunction, hemostasis and oxidative stress, insulin resistance, redistribution of adipose tissue and the very important role in the vitamin B12 economy and balance within the human body.
Authors and Affiliations
Onel A. F. M. , Cotoraci C. A. , Trofenciuc N. -M. , Verboczki G. E. , Popa A. R.
Keywords
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