Clinical and translational mode of single-cell measurements: clinical artificial intelligent single-cell

Journal Title: 中国临床医学(Chinese Journal of Clinical Medicine) - Year 2024, Vol 31, Issue 5

Abstract

With rapid development and maturity of single-cell measurements, single-cell biology and pathology has become an emerging discipline to understand the disease. However, it is important to address concerns raised by clinicians as to how to apply single-cell measurements for clinical practice, translate the signals of single-cell systems biology into determination of clinical phenotype, and predict patient response to therapies. This paper proposes a new system coined as the clinical artificial intelligent single-cell (caiSC) with the dynamic generator of clinical single-cell informatics, artificial intelligent analyzers, molecular multimodal reference boxes, clinical inputs and outputs, and AI-based computerization. This system provides reliable and rapid information for impacting clinical diagnoses, monitoring, and prediction of the disease at the single-cell level. The caiSC represents an important step and milestone to translate the single-cell measurement into clinical application, assist clinicians’ decision-making, and improve the quality of medical services. There is increasing evidence to support the possibility of the caiSC proposal, since the corresponding biotechnologies associated with caiSCs are rapidly developed. Therefore, we call the special attention and efforts from various scientists and clinicians on the caiSCs and believe that the appearance of the caiSCs can shed light on the future of clinical molecular medicine.

Authors and Affiliations

Xiangdong Wang, Powell Charles a. , Qin Ma, Jia Fan

Keywords

Related Articles

Aldehyde dehydrogenase 2 promotes wound healing by regulating M2 macrophage polarization

ObjectiveTo verify the role of aldehyde dehydrogenase 2 (ALDH2) in wound healing and to explore the underlying mechanisms. MethodsA murine excisional wound model was developed and mice were randomly assigned to control g...

Comparison of the efficacy of arthroscopically-assisted reduction and internal fixation combined with enhanced recovery after surgery and open reduction and internal fixation in the treatment of posterior lateral tibial plateau fractures

Objective To compare the clinical effects of arthroscopically-assisted reduction and internal fixation (ARIF) combined with enhanced recovery after surgery (ERAS) and open reduction and internal fixation surgery (ORIF) i...

Value of one-stop spectral scanning of computer tomography pulmonary angiography combined with abdominal-pelvic enhancement in the pre-operative evaluation for patients with gynecologic tumors

ObjectiveTo explore the value of one-stop spectral CT scanning of computer tomography pulmonary angiography (CTPA) combined with abdominal-pelvic enhancement in preoperative evaluation for patients with gynecological tum...

Application value of serum carbonic anhydrase Ⅲ as a new biomarker in the clinical diagnosis of Alzheimer disease

ObjectiveTo explore the application value and related factors of serum carbonic anhydrase Ⅲ (CAⅢ) in the clinical diagnosis of mild to moderate Alzheimer disease (AD). MethodsA total of 106 elderly patients initially...

The relationship between dietary fiber intake and hypertension: an analysis based on the NHANES data from 2015—2016 in the United States

ObjectiveTo explore the relationship between dietary fiber intake and hypertension in different populations. MethodsDietary fiber intake was calculated using the data from 2015—2016 National Health and Nutrition Examinat...

Download PDF file
  • EP ID EP749294
  • DOI 10.12025/j.issn.1008-6358.2024.20241086
  • Views 124
  • Downloads 0

How To Cite

Xiangdong Wang, Powell Charles a. , Qin Ma, Jia Fan (2024). Clinical and translational mode of single-cell measurements: clinical artificial intelligent single-cell. 中国临床医学(Chinese Journal of Clinical Medicine), 31(5), -. https://europub.co.uk/articles/-A-749294