Clinical and translational mode of single-cell measurements: clinical artificial intelligent single-cell
Journal Title: 中国临床医学（Chinese Journal of Clinical Medicine） - Year 2024, Vol 31, Issue 5
Abstract
With rapid development and maturity of single-cell measurements, single-cell biology and pathology has become an emerging discipline to understand the disease. However, it is important to address concerns raised by clinicians as to how to apply single-cell measurements for clinical practice, translate the signals of single-cell systems biology into determination of clinical phenotype, and predict patient response to therapies. This paper proposes a new system coined as the clinical artificial intelligent single-cell (caiSC) with the dynamic generator of clinical single-cell informatics, artificial intelligent analyzers, molecular multimodal reference boxes, clinical inputs and outputs, and AI-based computerization. This system provides reliable and rapid information for impacting clinical diagnoses, monitoring, and prediction of the disease at the single-cell level. The caiSC represents an important step and milestone to translate the single-cell measurement into clinical application, assist clinicians’ decision-making, and improve the quality of medical services. There is increasing evidence to support the possibility of the caiSC proposal, since the corresponding biotechnologies associated with caiSCs are rapidly developed. Therefore, we call the special attention and efforts from various scientists and clinicians on the caiSCs and believe that the appearance of the caiSCs can shed light on the future of clinical molecular medicine.
Authors and Affiliations
Xiangdong Wang, Powell Charles a. , Qin Ma, Jia Fan
Keywords
Related Articles
- EP ID EP749294
- DOI 10.12025/j.issn.1008-6358.2024.20241086
- Views 104
- Downloads 0
Clinical and translational mode of single-cell measurements: clinical artificial intelligent single-cell
With rapid development and maturity of single-cell measurements, single-cell biology and pathology has become an emerging discipline to understand the disease. However, it is important to address concerns raised by clini...
Application effect of different incision surgeries combined with respiratory function exercise under the guidance of enhanced recovery after surgery concept in patients with lung cancer
ObjectiveTo explore the efficacy of different incision surgeries combined with respiratory function exercise under the guidance of enhanced recovery after surgery (ERAS) in lung cancer patients. MethodsFrom January 2020...
Construction of a pilocarpine-induced temporal lobe epilepsy model in mice based on severe seizure behavior
Objective To explore the approach to establish a temporal lobe epilepsy model via intraperitoneal pilocarpine injection in C57BL/6J mice, and to summarize behavioral indicators predicting successful modeling during the a...
Application value of serum carbonic anhydrase Ⅲ as a new biomarker in the clinical diagnosis of Alzheimer disease
ObjectiveTo explore the application value and related factors of serum carbonic anhydrase Ⅲ (CAⅢ) in the clinical diagnosis of mild to moderate Alzheimer disease (AD). MethodsA total of 106 elderly patients initially dia...
Application value of serum carbonic anhydrase â ¢ as a new biomarker in the clinical diagnosis of Alzheimer disease
ObjectiveTo explore the application value and related factors of serum carbonic anhydrase â ¢ (CAâ ¢) in the clinical diagnosis of mild to moderate Alzheimer disease (AD). MethodsA total of 106 elderly patients initially...