Clinical characteristics of liver failure from a systemic cause: A report from an advanced critical care center
Journal Title: Annals of Hepatology - Year 2016, Vol 15, Issue 2
Abstract
Background/Purpose. In Japan, acute liver failure (ALF) has generally been described using the diagnostic term, “fulminant hepatitis”, because of the fact that most cases of ALF has been thought to occur in association with hepatitis mainly due to a hepatitis virus infection. New diagnostic criteria for ALF, including ALF other than fulminant hepatitis, were established in 2011. Wetherefore examined the prognostic factors of patients with liver failure from a systemic cause, including warfarin users. Materialand methods. Sixty-six patients with ALF that were diagnosed according to the Japanese diagnostic criteria for ALF between2009 and 2013 were divided into a survivor group and a non-survivor group. The data regarding demography, liver tests, coagulation tests, Sequential Organ Failure Assessment (SOFA) scores, and the use of oral warfarin or aspirin were compared between the two groups. Results. The SOFA score was significantly higher in the non-survivor group (p = 0.025). The proportion of oral warfarin users was significantly higher in the survivor group (p = 0.013) (58.1% vs. 26.1%). A multivariate logistic regression analysis showed the SOFA score (odds ratio: 0.851, 95% confidence interval (CI): 0.728-0.995, p = 0.043) and warfarin use (odds ratio: 3.261, 95% CI: 1.028-10.347, p = 0.045) to be significant factors that were negatively and positively associated with the prognosis, respectively. Conclusion. In this study, among the patients with ALF other than fulminant hepatitis, those with a high SOFA score on admission exhibited a poor prognosis. In addition, oral warfarin use prior to disease onset was found to be a factor which indicated a good prognosis.
Authors and Affiliations
Makoto Onodera, Yoshihiro Inoue, Yasuhiro Takikawa, Shigeatsu Endo
Keywords
Related Articles
- EP ID EP78563
- DOI -
- Views 140
- Downloads 0
De-novo cholangiocarcinoma in native common bile duct remnant following OLT for primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a chronic, progressive, inflammatory and obstructive disease of the intra- and extra-hepatic bile ducts of unknown etiology. Currently, orthotopic liver transplantation (OLT) is th...
Elevated circulating levels of IL-21 and IL-22 define a cytokine signature profile in type 2 autoimmune hepatitis patients
Background and aims. Autoimmune hepatitis (AIH) is a chronic inflammatory condition of the liver in which the immunologicalmechanisms involved in tissue destruction and/or repair are still unclear. Different pro-inflamm...
The role of zinc in liver cirrhosis
Zinc is an essential trace element playing fundamental roles in cellular metabolism. It acts mostly by binding a wide range of proteins, thus affecting a broad spectrum of biological processes, which include cell divisio...
Nonalcoholic fatty liver disease in Brazil. Clinical and histological profile
Background. The epidemiology and clinical characteristics of nonalcoholic fatty liver disease (NAFLD) in South America are not well known. Brazil is a largest country in this part of the world and the present study aimed...
Epidemiology of HCC in Brazil: incidence and risk factors in a ten-year cohort
Background and aim. The lack of information about hepatocellular carcinoma (HCC) in Brazil weakens health policy in preventing deaths from the illness. The aim of this study was to establish the cumulative incidence and...