CLINICAL COURSE AND EFFICACY OF ANTIRETROVIRAL THERAPY OF COMBINES BLOODBORNE PATHOLOGY: HUMAN IMMUNODEFICIENCY VIRUS AND CHRONIC HEPATITIS C
Journal Title: Молодий вчений - Year 2017, Vol 4, Issue 44
Abstract
Pre-existing viral liver disease increases the risk of realization of potential hepatotoxicity of antiretroviral drugs, on the other hand, a number of drugs for the treatment of HIV infection alone may alter the pharmacokinetics of other drugs acting on cytochrome P450, inhibiting or stimulating their activity. At the same time, the interaction of these drugs may be advantageously used in combination therapies to maintain appropriate concentrations in plasma antiretrovirals. Antiretroviral therapy for chronic hepatitis C and HIV-infected patients becomes important, due to the possibility of eradicating HCV infection, delayed progression of viral infection of the liver to prevent the development of fibrosis, cirrhosis, decompensation and onset of death. In co-infected patients with early antiretroviral HCV therapy due to the compensation of hepatic functions may improve the tolerability of subsequent antiretroviral therapy and reduce its hepatotoxic potential, thereby positively affecting the commitment of patients to treatment, improve the effectiveness of therapy by reducing the incidence of HIV-associated morbidity and mortality.
Authors and Affiliations
L. A. Kravchenko
Keywords
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