Clinical evaluation of effects of Intravenous Induction agents: propofol, ketamine and etomidate on blood sugar level

Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 1

Abstract

Background: Hyperglycaemia is one of the stress responses to surgery and anaesthesia. Studies reported that volatile anaesthetics mainly sevoflurane impaired glucose use, suggesting a possible contribution to intraoperative hyperglycaemia. Aim: To establish an effect if any on blood sugar by IV induction agents. Methods: It is a prospective observational study. We selected 90 patients of either sex, ages between 18- 55 yrs, ASA grade I /II undergoing elective minor surgical procedures with expected duration of 10-15 mins. All patients were divided into three groups (n =30 each);Group –A : received propofol 2 mg/kg, Group-B : received ketamine 2 mg/kg, Group – C : received etomidate 0.3 mg/kg. Blood sugar levels were measured before giving induction agents ( at 0 min , taken as baseline ) then at 5 mins,15 mins, 30 mins, 60 mins,90 mins and 120 mins interval. Hemodynamic parameters like heart rate (HR), mean arterial pressure (MAP) were also measured at similar time interval as blood glucose level. The values of each time interval was compared with respect to baseline value within a group by independent sample t-test. Results: There were no significant differences between groups with respect to age, weight, gender distribution and duration of surgery. There was no significant change in blood glucose level in propofol. Ketamine increased blood sugar level which was statistically significant (p < 0.05) after 30 mins and 60 minutes from its administration but did not produce clinically significant hyperglycemia (> 180 mg/dl) at any of the study interval. Etomidate decreased blood glucose level which was significant ( p < 0.05 ) after 2 hrs but was within the physiological range. Blood sugar level never decreased to < 60mg/dl. Propofol showed significant decrease in HR and MAP after 5 mins of giving induction agent. Ketamine showed significant increase (p < 0.05) in HR at 5 mins and 15 mins after giving induction agent. Etomidate showed no significant changes in HR & MAP. Conclusion: Intravenous induction agents also result in impaired glucose response, though the changes are within physiological limits. Hyperglycemia occured with ketamine.

Authors and Affiliations

Alok Kumar Sahoo

Keywords

Related Articles

Serum Apolipoprotein A-Iv Level in HCV Related Liver Diseases

Background: Hepatitis C virus (HCV) is a globally prevalent pathogen and chronic infection eventually causes cirrhosis leading to hepatocellular carcinoma (HCC) and ultimately death. Accurate assessment of liver fibrosis...

Prognostic factors in Spontaneous Hypertensive Intracerebral Hemorrhage

Background: Stroke is a major cause of death and disability. Haemorrhagic strokes constitute 20% of all strokes. Most important risk factor for development of spontaneous intracerebral haemorrhage is systemic hypertensio...

Post-Operative Analgesia in Children: A Comparison between Caudal Bupivacaine with Buprenorphine and Caudal Bupivacaine with Rectal Diclofenac

Background: Relief of post-operative pain is provided traditionally by single drug regimens but combinations of different regimens have been suggested to be more rational and effective. Rectal administration of NSAIDs in...

Cord blood Hemoglobin and Red Blood Cell Indices in Term, Term IUGR and Preterm Babies in Northern Kerala – A comparative study

Background: Cord blood Hemoglobin and Red Blood Cell Indices are frequently done in newborn babies as a part of routine evaluation. About one third babies are born pre term in India. Objectives: This study was undertaken...

Download PDF file
  • EP ID EP502320
  • DOI -
  • Views 102
  • Downloads 0

How To Cite

Alok Kumar Sahoo (2018). Clinical evaluation of effects of Intravenous Induction agents: propofol, ketamine and etomidate on blood sugar level. Journal of Medical Science And clinical Research, 6(1), 32363-32369. https://europub.co.uk/articles/-A-502320