Clinical, immunophenotypic and genetic characteristics of infant acute lymphoblastic leukemia
Journal Title: Postępy Nauk Medycznych - Year 2013, Vol 26, Issue 9
Abstract
Introduction. Acute lymphoblastic leukemia (ALL) diagnosed in the first year of life is a rare disease, comprising 2-5% of all childhood ALL cases. The data on infant ALL in Poland published until now are based on small patient groups or concern case reports. Important information, particularly concerning genetic and immunophenotypic data is still not available.Aim. The study aimed at comprehensive clinical, immunophenotypic and genetic characteristic of infant ALL in Poland.Material and methods. The study group consisted of 36 infants treated for ALL at the hemato-oncologic centers of Polish Pediatric Leukemia and Lymphoma Study Group according to INTERFANT protocols. The control group comprised 53 childhood ALL patients treated in the same time period at the Department of Pediatric Hematology and Oncology of the Medical University of Silesia in Zabrze according to the ALL-IC BFM 2002 treatment protocol.Results. Infant ALL is characterized by more severe presentation as compared to ALL in older children. This is reflected by significantly higher initial leukocytosis, more frequent hepatosplenomegaly and central nervous system involvement. MLL gene aberrations are hallmark of infant ALL and are associated with pro-B-ALL immunophenotype. Infant ALL is characterized by significantly worse response to treatment (more frequent steroid-resistance, higher relapse rate) as compared to ALL in older children.Conclusions. Clinical, immunophenotypic and genetic characteristics as well as treatment course and therapy results of infant ALL in Poland are fully comparable to other European and world countries.
Authors and Affiliations
Lidia Kajdas, Łukasz Sędek, Jacek Karpe, Walentyna Balwierz, Magdalena Ćwiklińska, Katarzyna Drabko, Jerzy Kowalczyk, Benigna Konatkowska, Jan Styczyński, Mariusz Wysocki, Ninela Irga, Anna Balcerska, Michał Matysiak, Elżbieta Latos-Grażyńska, Alicja Chybicka, Maryna Krawczuk-Rybak, Grażyna Sobol-Milejska, Agnieszka Mizia-Malarz, Tomasz Szczepański
Keywords
Related Articles
- EP ID EP54788
- DOI -
- Views 148
- Downloads 0
Assessment of vitamin D supplementation in the Warsaw’s children after infancy – a preliminary study
Introduction. An adequate concentration of blood 25-hydroxyvitamin D promotes pleiotropic actions of vitamin D.Aim. The aim of the study was to assess the vitamin D status in the Warsaw’s children after infancy. Study da...
Stany przedrakowe i raki przedinwazyjne skóry – ostatnie doniesienia
Proces karcinogenezy w obrębie skóry obejmuje szereg etapów, które mogą być inicjowane i stymulowane przez różne czynniki fizyczne i chemiczne, przewlekłe zapalenie oraz infekcje wirusowe.Stany przedrakowe i raki in situ...
Iliac artery aneurysms – underestimated problem of vascular surgery
Iliac artery aneurysms (IAA) are underestimated problem of vascular surgery. Their atypical medical manifestations cause that iliac aneurysms are dicovered accidentaly or in late stage of disease. High mortality due to r...
Current indications and principles for autologous haematopoietic cell transplantation
High dose chemotherapy with autologous haematopoietic stem cell transplantation may result in clinical improvement in many patients with haematological neoplasms, solid tumours and autoimmune diseases. According to EBMT...
Zespół psychoendokrynny w wybranych endokrynopatiach
Od początku XX wieku obserwuje się zainteresowanie związkami pomiędzy endokrynologią a psychiatrią. Pomimo postępu medycyny doświadczalnej wzajemne, złożone relacje pomiędzy ośrodkowym układem nerwowym a układem endokryn...