Occurrence of minor histocompatibility antigens’ disparities in allogeneic hematopoietic stem cell transplantation recipients and their HLA-matched siblings
Journal Title: Postępy Nauk Medycznych - Year 2011, Vol 24, Issue 7
Abstract
We have determined the alleles of eleven minor histocompatibility antigens (mHAgs) and investigated the occurrence of immunogenic mHAgs mismatches between a donor and a recipient of allogeneic hematopoietic stem cell transplantation (alloHSCT) from HLA-matched sibling donors in 35 recipients after myeloablative conditioning between 2000 and 2008.Mismatches were either graft-versus-host or host-versus-graft directed. The frequency analysis of mHAg alleles, genotypes and phenotypes accompanied by appropriate restriction HLA antigens allowed for estimation of the probability of immunogenic mismatches. The investigation of the association of detected immunogenic mHAgs mismatches between a donor and a recipient with a course of alloHSCT is warranted.
Authors and Affiliations
Monika Dzierżak-Mietła, Mirosław Markiewicz, Urszula Siekiera, Sławomira Kyrcz-Krzemień
Keywords
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