Clinical Out Come with Single Dose Ondansetron versus Domperidone in Paediatric Gastroenteritis – Our Experience
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 6
Abstract
Background: Acute gastroenteritis (AGE) is a diarrheal disease of rapid onset, with or without accompanying symptoms and signs, such as nausea, vomiting, fever, or abdominal pain. The WHO recommends ORS as the treatment of choice for children with mild to moderate gastroenteritis in both developed and developing countries. Vomiting limits the success of oral rehydration in children with gastroenteritis. Ondansetron has been proven safe and effective in chemotherapy induced and post operative vomiting. It is a selective serotonin 5HT-3 receptor blocker and inhibits the initiation of the vomiting reflex in the periphery. We have evaluated single dose of ondansetron versus domperidone on clinical outcome in paediatric gastroenteritis. Methods: It is an open-label randomized study was undertaken at department of Pediatrics, Narayana Medical College, Nellore for a period of six months. A total 84 children, age group between 3- 10 years of age were selected for the study. The patients were randomly assigned to receive Ondonsetron or Domperidone and were stratified according to the dose of medication. The bedside nurse or care giver is instructed to administer the medication. Vomiting episodes were tabulated in 24 hrs starting from the time of drug administration until cessation of vomiting. The primary outcomes recorded were the need and duration for oral / intravenous rehydration and hospitalization. Data was presented as Mean, SD, Range, actual numbers and Percentages. Statistical analysis was carried by using paired t test. Results: Out of 84 children in each group whose data were analyzed, 42 patients received ondansetron and remaining 42 received domperidone along with oral-rehydration therapy. As compared with children who received domperidone, children who received ondansetron were less likely to vomit (12 percent vs. 37 percent; relative risk, 0.44; 80 percent confidence interval with P<0.001) Conclusion: In children with acute gastroenteritis with vomiting, a single dose of ondansetron reduces vomiting and well tolerated with oral rehydration therapy compared to domperidone
Authors and Affiliations
SK Salma Kamal
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