Clinical outcome of the axilla after axillary radiation in breast cancer: A retrospective study from MNJIO & RCC Hyderabad
Journal Title: Journal of Medical and Scientific Research - Year 2018, Vol 6, Issue 3
Abstract
Aim: To study the axillary recurrences after calculation of radiation dose delivered to the mid axillary plane in breast cancer patients receiving adjuvant radiation. Materials: 208 patients (148 cobalt, 60 linear accelerator) attending the follow up clinics from May 2007 to Dec 2012, had their axillary separation measured at the first visit and the dose to mid plane of axilla was extrapolated from PDD’s. Results: The actual mean dose received by the axilla was in the cobalt arm 4058.9 cGy (range 3301cGy to 4705cGy) and 4134.77 cGY (range 3597cGy to 4824cGy) in the LA arm, which is less than the usual recommended dose of 4500cGy to 5000cGy to midplane. The doses were subclinical as posterior axillary boost was not planned. There were 10 recurrences including only 1 axillary recurrence (0.48%). Discussion: The role of PMRT in breast cancer is well established and so is the morbidity of combined axillary dissection and radiation. The adoption of certain techniques of planning can result in sub optimal doses to the axillary mid plane. However suboptimal dosing may not affect the outcome of axillary recurrences. Conclusion: The incidence of axillary recurrences in a heterogeneous population receiving locoregional post-mastectomy radiation to the axilla is less than one percent in the region of Andhra Pradesh.
Authors and Affiliations
Raman RR
Keywords
Related Articles
- EP ID EP595953
- DOI 10.17727/JMSR.2018/6-11
- Views 52
- Downloads 0
Impact of artificial intelligence in chest lesions
Since the discovery of x-rays by Wilhelm Conrad Rontgen in 1895, the utility of these new rays has extensively adopted in medicine to diagnose, prognosticate and manage many of the maladies of man. Radiograph of the ches...
The role of Bak-mediated dissipation of mitochondrial membrane potential in radiosensitivity of Bax-negative human prostate cancer cells
In the radiotherapy of localised cancers, susceptibility of tumour and normal cells to undergo radiation-induced programmed cell death is an important prognostic factor. Mitochondria-mediated cell death is often preceded...
Ramipril induced pemphigoid vulgaris
Introduction: Angiotensin-converting enzyme (ACE) inhibitors are the very frequently used drugs in the treatment of hypertension & heart failure. ACE inhibitors competitively inhibit the conversion of angiotensin I to an...
Robotic surgery a boon in medical science
Objectives: To compare the outcomes of robotic assisted laparoscopic versus open hysterectomy with pelvic lymphadenectomy in endometrial cancer. Methods: Prospective analysis done for the two cohorts underwent hysterect...
Tumoral lesions of the bones of the hands - Pictorial essay
All swellings of the fingers and hand are not neoplastic. The benign tumors of the bones of the hands and their radiographic manifestations have been described in the previous article. Conventional radiographs of the han...