Clinical Profile and Complications in Sickle Cell Disease and Its Variants in Central India
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 6
Abstract
Objective: Sickle cell anemia is a hereditary anemia, with nearly 50% of the world population affected by sickle cell disease reside in India. Complications of sickle cell disease increases morbidity. This study was designed to asess the clinical profile and complications of sickle cell anemia and its variants. Method: Hospital based cross-sectional observational study was undertaken among adolescent and adult patients conducted at Hamidia Hospital Bhopal. A total of 50 patients were studied and analysed. Clinical features and complications were noted and compared with previous studies. Results: Males are found to be predominantly affected by sickle cell disease with male to female ratio of nearly 3:2.Most common symptoms of presentation are Bone pain and Abdominal pain. Most common signs are Pallor, Fever and Splenomegaly. Splenomegaly was found more common in the adolescent age group. Vaso-occlusive crisis is the most common crisis of presentation. Conclusion: Sickle cell disease is one among the common presentations of anemias in central India. Prevalent in females more than males with morbidity and mortality affecting adolescent and early adult population. Bone pain and pallor are common symptoms and signs of the disease with significant presence of splenomegaly, particularly in sickle-thalassemia patients.
Authors and Affiliations
Ashwin D K
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