Clinical Profile and Complications in Sickle Cell Disease and Its Variants in Central India
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 6
Abstract
Objective: Sickle cell anemia is a hereditary anemia, with nearly 50% of the world population affected by sickle cell disease reside in India. Complications of sickle cell disease increases morbidity. This study was designed to asess the clinical profile and complications of sickle cell anemia and its variants. Method: Hospital based cross-sectional observational study was undertaken among adolescent and adult patients conducted at Hamidia Hospital Bhopal. A total of 50 patients were studied and analysed. Clinical features and complications were noted and compared with previous studies. Results: Males are found to be predominantly affected by sickle cell disease with male to female ratio of nearly 3:2.Most common symptoms of presentation are Bone pain and Abdominal pain. Most common signs are Pallor, Fever and Splenomegaly. Splenomegaly was found more common in the adolescent age group. Vaso-occlusive crisis is the most common crisis of presentation. Conclusion: Sickle cell disease is one among the common presentations of anemias in central India. Prevalent in females more than males with morbidity and mortality affecting adolescent and early adult population. Bone pain and pallor are common symptoms and signs of the disease with significant presence of splenomegaly, particularly in sickle-thalassemia patients.
Authors and Affiliations
Ashwin D K
Keywords
Related Articles
- EP ID EP286150
- DOI -
- Views 30
- Downloads 0
Septo-Optic Dysplasia: A Case Report
Septo-optic dysplasia also referred to as de Morsier syndrome and is a disorder of early brain development. Three characteristic features are under development (hypoplasia) of the optic nerve, abnormal formation of struc...
Intraoperative Hypotension: A Surgeon’s Nightmare
Sudden intraoperative hypotension can prove to be a lethal emergency. Awareness of the possible causes and risk factors is essential to prevent this complication. Close monitoring of the patient during the procedure foll...
Study of Serial Serum Sodium Values in Decompensated Liver Disease Patients during the Phase of Hepatic Encephalopathy
Background: Hepatic encephalopathy is a dreaded complication of chronic liver disease patients in the decompensated state, associated with high percentage of mortality. Decompensated liver disease is associated with lowe...
A Study to Assess Treatment response and Pattern among Lung Cancer Patients in a Tertiary Care Hospital of India
Introduction: Lung cancer is among the five main types of cancer leading to overall cancer mortality contributing about 1.3 million deaths/year globally. There are only few Indian studies on bronchogenic carcinoma in pat...
Effect of Intravenous Fentanyl and Magnesium Sulphate in General Anesthesia and Surgery During Peri-Operative Period – A Randomized Comparative Study
Aim and Background: Success of all major and specialized surgical procedures under general anesthesia depends on balanced anaesthetic techniques, with minimal hemodynamic disturbance to the patients. Aim of this study is...