Clinical profile and etiology of thyroid disorders in children at a tertiary care hospital

Journal Title: Medpulse International Journal of Pediatrics - Year 2019, Vol 9, Issue 1


Background: Congenital hypothyroidism is the most common preventable cause in India and worldwide. Thyroid hormones deficiency in infancy leads to irreversible impairment of neuro-cognitive function and physical and mental retardation. The disorders of thyroid hormone can be due to diseases of the thyroid gland itself (primary), secondary to pituitary disorder (secondary) or due to hypothalamic diseases (tertiary). Aim: To determine clinical profile and etiology of thyroid diseases in children. Material and Methods: A hospital based prospective observational study performed in new-borns and children below 18 years if they had clinical suspicion of thyroid dysfunction. Thyroid profile were done if there was suspicion of hypothyroidism and Free T3 and TSH if there was suspicion of hyperthyroidism. Other investigations like USG thyroid, thyroid 99m technetium scan anti TPO and anti TG antibody levels were done to look for the etiological diagnosis. Results: The mean age of patients was 10.67±4.23 years with male to female ratio of 1:3.6. Out of 70 cases, 67 cases (95.7%) were hypothyroidism and 3 cases (4.3%) were hyperthyroidism. The most common clinical presentation in patients with hypothyroidism was constipation 37 cases (55.2%) and in patients with hyperthyroidism palpitations was most common in 3 cases (100%). Out of 57 cases having suspicion of autoimmune aetiology, 44 cases (77.19%) had elevated anti TPO antibodies and 49 (85.96%) cases had elevated anti TG antibodies. Conclusion: Congenital hypothyroidism is one of the major preventable thyroid disease if diagnosed early. Hence, screening of all newborns and children should be mandatory. Autoimmune thyroid diseases are now the major leading cause of thyroid disorders in childhood.

Authors and Affiliations

Sharanagouda Patil, Kudlappa P Angadi, Abhishek Kharge


Related Articles

Catheter related infections in children on continuous ambulatory peritoneal dialysis at tertiary care hospital in Mumbai

Context: Continuous ambulatory peritoneal dialysis (CAPD) is a bridge between ESRD and renal transplant. One of the factors hindering the widespread use of CAPD in children is the high risk of infections and subsequent n...

Role of serum zinc level in simple febrile seizures: A hospital based study from rural area of Maharashtra

Introduction: Febrile Convulsion is the most common type of seizure in children between 5 months to 6 years of age. Low levels of serum zinc suggestive of increased incidence of simple febrile seizure. Aim: The aim of th...

Maternal and foetal risk factors predicting outcome of bubble CPAP in babies with respiratory distress

Background: Respiratory distress is most common and serious complication in relation with various maternal and foetal risk factors, which together account for over one-half of all neonatal deaths globally. The respirator...

Incidence and pattern of congenital heart disease in a tertiary care hospital

Background: To find the prevalence and pattern of congenital heart diseases (CHD) at a teaching hospital in Warangal, Telangana State, India. Materials and Methods: It was a prospective study conducted in the department...

Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyper responsiveness and clinical asthma in nonsteroiddependent asthma in children

Several short-term studies have shown that inhaled steroids can reduce airway hyper responsive in asthma. To evaluate whether prolonged treatment can bring about full recovery, this double blind, randomized, control tria...

Download PDF file
  • EP ID EP469569
  • DOI 10.26611/10149112
  • Views 107
  • Downloads 0

How To Cite

Sharanagouda Patil, Kudlappa P Angadi, Abhishek Kharge (2019). Clinical profile and etiology of thyroid disorders in children at a tertiary care hospital. Medpulse International Journal of Pediatrics, 9(1), 39-42.