Clinical profile and outcome of patients with ACLF at a tertiary care centre
Journal Title: Medpulse International Journal of Medicine - Year 2019, Vol 9, Issue 2
Abstract
Background and Objectives: Acute-on-chronic liver failure (ACLF) is a syndrome characterised by acute decompensation of chronic liver disease associated with organ failures and high short term mortality. we carried out this study to analyse aetiology, clinical profile and outcome of patients with ACLF at a tertiary care centre. Methods: This is a prospective study of 72 patients satisfying APASL definition of ACLF admitted at our institute which is a tertiary care centre. Aetiology of acute precipitating insult and chronic liver disease and outcomes were assessed. Severity of disease and prognosis were assessed by CTP and MELD score. Results: Among acute insults Hepatitis E virus infection in 45.8% of patients was the most common trigger at our centre followed by alcohol binge in 30.5%. Alcohol was found to be the most common aetiology of CLD in 72.2% of patients. In hospital mortality was 31.9%. Conclusion: This study highlights that hepatitis E virus infection is the most common acute insult. Leucocytosis, altered serum creatinine, impaired INR and MELD score were found to be the independent predictors of mortality among the patients of ACLF. Alcoholic Liver disease was the most common underlying CLD
Authors and Affiliations
Amin BK, Talsaniya K, Gondaliya HH, Nandaniya BA, Banker SD
Keywords
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- EP ID EP463506
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