Clinical profile of mortality predictors in Leptospirosis:a prospective study in a tertiary care center
Journal Title: International Journal of Medical Research and Review - Year 2017, Vol 5, Issue 9
Abstract
Aims and Objectives: To look for mortality predictors of Leptospirosis, with specific importance given to oli-guric renal failure and hypotension as possible predictors.Materials and Methods: A Prospective Cohort study conducted over two years which enrolled patients with clinically and serologically confirmed Leptospirosis. Of these, 30 patients were included who had hypotension and 30 patients who had oliguric renal failure, as per statistical requirements. Epidemiological, clinical, and laboratory data was collected at admission and the patients were followed up to look for outcome (discharge/death).Results: A total of 83 patients were included in this study. Of these 8 patients died (Mortality of 9.6%). Data analysis with Chi Square Test showed that oliguric renal failure was significantly associated with mortality in Leptospirosis (p<0.05). Other factors were also found which were associated with mortality including elevated bilirubin and AST levels, anemia, Type 2 Diabetes Mellitus, Alcohol Dependence Syndrome, and Chronic Liver Disease. However, hypotension was found to not be significantly associated with mortality. Conclusion: In patients with Leptospirosis, significant mortality pre-dictors included oliguric renal failure, elevated bilirubin and AST levels, anemia, Type 2 Diabetes Mellitus, Alcohol Dependence Syndrome, and Chronic Liver Disease.
Authors and Affiliations
Arun Divakar, M. Gopala Krishna Pillai, Elizabeth Thomas
Keywords
Related Articles
- EP ID EP274681
- DOI 10.17511/ijmrr. 2017.i09.05
- Views 198
- Downloads 0
Comparative study of low dose magnesium sulphate regime with Pritchard regime in eclampsia
Introduction: Eclampsia is still a leading cause of maternal mortality and morbidity. Magnesium sulphate despite being an anticonvulsant of choice remains underutilized due to fear of toxicity. Average weight of Indian w...
Interrelationship of serum TSH with BMI in patients with thyroid disorders
Introduction: The endocrine system is evaluated primarily by measuring hormone concentrations, thereby arming the clinician with valuable diagnostic information. Thyroid Hormones which increase the basal metabolic rate a...
Bacteriological analysis of the drinking water from different schools in Northern India: A concern in developing countries
Introduction: Potable water is an essential ingredient for good health and the socio-economic development of man. In developing countries, biological contamination of drinking water is a major concern for public health a...
Neonatal Kasabach-Merritt Syndrome (KMS): case report
A 2days baby girl presented with congenital reddish-blue swelling over chest and abdomen with thrombocytopenia. The clinical, imagining and laboratory findings suggested the diagnosis of KMS. Oral steroid was started wit...
A clinico hematological correlation of autoimmune hemolytic anemia and its clinical implication
Introduction: Autoimmune hemolytic anemia characterized by production of antibodies that attach to Red cells resulting in their destruction causing anemia. AIHA could be primary or secondary to some other cause. The posi...