Clinical Profile of Patients with Brain Metastasis- A Single Institutional Retrospective Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Brain metastases are the commonest type of intracranial neoplasm, with an annual incidence of about 1, 70, 000 to 2, 00, 000 cases in United States. Metastatic brain tumors outnumber primary brain tumor by a ratio of 10:1, with an occurrence rate of about 25% in all cancer patients. Autopsy series demonstrating a 20% to 40% rate of brain metastases for all patients with a diagnosis of cancer. However, heterogeneous data exist regarding demographic and clinical profile of brain metastases. Aims: This study was conducted retrospectively with the aim to know the social, demographic and clinical profile of patients with brain metastases. Material and Methods: A retrospective, single institutional study of 115 patients with brain metastases was carried out from January 2013 to January 2016. The data related to patients collected from review of hospital records and entered in a standardized case record form. Details regarding clinical history, primary diagnosis, histological diagnosis and imaging findings obtained. Results: Majority of the cases were female in 6th decade of life. Breast cancer was the most common primary causing brain metastases followed by carcinoma lung. Adenocarcinoma was the commonest histology of the primary that lead to metastases. On imaging (CT or MRI) multiple metastases were more common than single metastases. Supratentorial lesions were more common compared to infratentorial lesions. Parietal lobe of brain was most commonly involved. Brain metastases were common in the patients with uncontrolled primary. Conclusions: Present study concludes that brain metastases are more common in older patients. Common causes of metastatic brain disease are breast and lung cancer. Adenocarcinoma is the commonest histology of primary causing brain metastases and cerebral hemisphere are most commonly involved site.
Authors and Affiliations
Manashi Ghosh, Kaustav Mandal, Vinita Trivedi, Richa Chauhan, Santosh Shubham, Muneer A
Keywords
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