Clinical profile of Spondarthritis in females as compared to male patients with reference to HLAB27: A single center study from Nepal
Journal Title: Journal of Advances in Internal Medicine - Year 2013, Vol 2, Issue 1
Abstract
Background and Aims-To study the differences in clinical parameters between male and female patients with spondarthritis (SpA) in Nepalese population; to study the prevalence of HLA B27 phenotype in Nepalese patients with SpA and to study the differences in clinical parameters in relation to HLA B27 phenotype. Methods- This is cross sectional observational study of 102 patients diagnosed with SpA attending rheumatology clinic at Alka Hospital, Nepal from September 2011 to February 2012. Electronic clinical registry was maintained and HLA B27 was performed by flowcytometry. Results- A total of 102 patients with SpA were enrolled in the study with male to female ratio of 1.8:1 . The mean age of male patients was 6±3 years lower than that of female patients (p=0.05). There were no other statistically significant differences in clinical parameters or prevalence of HLA B27 in both the genders. Of the total patients, 52.9% were HLA B27 positive. Presence of HLA B27 was associated with early presentation by 7.1±2.8 years and the occurrence of inflammatory spinal pain (P <0.001). Statistically significant association of HLA B27 with other clinical manifestations of SpA were not seen. Conclusions- HLA B27 was present in 52.9% of patients with diagnosed SpA. The presence of HLA B27 was associated with earlier presentation of disease and occurrence of inflammatory spinal pain. However, there was no gender difference in clinical manifestation of SpA or prevalence of HLAB27 in our patients except for early age at presentation in male patients.
Authors and Affiliations
Binit Vaidya*| Alka Hospital, Jawalakhel, Kathmandu, Nepal, Shweta Nakarmi| Alka Hospital, Jawalakhel, Kathmandu, Nepal, Pujan Batajoo| Nepal Medical College, Kathmandu, Nepal
Keywords
Related Articles
- EP ID EP4760
- DOI http://dx.doi.org/10.3126/jaim.v2i1.7628
- Views 542
- Downloads 23
Tuberculosis status among patients visiting antiretroviral therapy centers of Seti Zonal Hospital and Mahakali Zonal Hospital of far western Nepal
Background and aims: Tuberculosis is still a major public health problem in Nepal. The situation is further worsened by the widespread epidemic of HIV. Knowledge of TB/HIV co-infection is essential for effective dual cas...
-119C/G in MYG1 Gene and 49A/G in CTLA4 Gene Polymorphisms in Turkish Patients with Vitiligo
Vitiligo is a disease characterized by sharply limited white macular depigmentation as a result of melanocyte loss. Disease is divided into three types according to prevalence and localization as localized, general and u...
IN VITRO EVALUATION OF SOME SOIL RHIZOSPHERE BACTERIA FOR BIOLOGICAL CONTROL OF STRIGA HERMONTHICA (DEL.) BENTH
Striga hermonthica is a devastating root parasitic weed on cereals. In the present investigation a series of laboratory experiments was undertaken to study the effects of some soil borne bacteria on germination and haust...
BEHAVIOUR AND FATE OF 14C-2,4-DICHLOROPHENOXYACETIC ACID IN MALAYSIAN RICE MODEL AGROECOSYSTEM LYSIMETERS
Behavior and fate of 14C-2,4-dichlorophenoxyacetic acid (2,4-D) was studied in a Malaysian rice model agroecosystem. This model agroecosystem that consists of ricefield soil obtained from the Muda rice granary area, rice...
Association of hsCRP and soluble fraction of E-selectin with diabetic and non-diabetic individuals
Background and aims: It is known that endothelial dysfunction and low-grade inflammation are important element of diabetic complications. The soluble E-selectin is a marker of endothelial dysfunction and C-reactive prote...