Clinical profile of Spondarthritis in females as compared to male patients with reference to HLAB27: A single center study from Nepal
Journal Title: Journal of Advances in Internal Medicine - Year 2013, Vol 2, Issue 1
Abstract
Background and Aims-To study the differences in clinical parameters between male and female patients with spondarthritis (SpA) in Nepalese population; to study the prevalence of HLA B27 phenotype in Nepalese patients with SpA and to study the differences in clinical parameters in relation to HLA B27 phenotype. Methods- This is cross sectional observational study of 102 patients diagnosed with SpA attending rheumatology clinic at Alka Hospital, Nepal from September 2011 to February 2012. Electronic clinical registry was maintained and HLA B27 was performed by flowcytometry. Results- A total of 102 patients with SpA were enrolled in the study with male to female ratio of 1.8:1 . The mean age of male patients was 6±3 years lower than that of female patients (p=0.05). There were no other statistically significant differences in clinical parameters or prevalence of HLA B27 in both the genders. Of the total patients, 52.9% were HLA B27 positive. Presence of HLA B27 was associated with early presentation by 7.1±2.8 years and the occurrence of inflammatory spinal pain (P <0.001). Statistically significant association of HLA B27 with other clinical manifestations of SpA were not seen. Conclusions- HLA B27 was present in 52.9% of patients with diagnosed SpA. The presence of HLA B27 was associated with earlier presentation of disease and occurrence of inflammatory spinal pain. However, there was no gender difference in clinical manifestation of SpA or prevalence of HLAB27 in our patients except for early age at presentation in male patients.
Authors and Affiliations
Binit Vaidya*| Alka Hospital, Jawalakhel, Kathmandu, Nepal, Shweta Nakarmi| Alka Hospital, Jawalakhel, Kathmandu, Nepal, Pujan Batajoo| Nepal Medical College, Kathmandu, Nepal
Keywords
Related Articles
- EP ID EP4760
- DOI http://dx.doi.org/10.3126/jaim.v2i1.7628
- Views 560
- Downloads 23
Effect of a yoga intervention on hypertensive diabetic patients
Background - The concept of psychosomatic medicine has gained popularity, with yoga racing ahead in the field. The present study was conducted to assess the effectiveness of yoga as an intervention in the management of p...
Etiological profile, gender difference and age group patterns of 415 patients presenting with lower gastrointestinal bleeding in the western region of Nepal
Background: Lower gastrointestinal bleeding (LGIB) is a common clinical condition associated with significant morbidity and mortality. The aims of our study were to determine the etiological profile, gender difference an...
Concurrent multiple intracranial and intramedullary tuberculoma: a rare form of neurotuberculosis
Central nervous system tuberculosis is a serious form of tuberculosis. Tuberculous CNS involvement can occur in the form of TB meningitis, tuberculous Vasculitis, tuberculoma and rarely brain abscess. Tubercular granulom...
Falsely Elevated Acetaminophen Levels in the Setting of Hyperbilirubinemia
A 51-year-old male with a history of heavy alcohol abuse presented with alcoholic hepatitis and acute renal failure. Although he denied acetaminophen (APAP) ingestion, he was found to have elevated APAP levels that persi...
An atypical hydronephrosis revealing urinary tract involvement in antiphospholipid syndrome
Urinary tract involvement is rarely described in antiphospholipid syndrome (APS). We report the case of a 40 year-old man with primitive APS who developed an arterial and venous unilateral ureteral ischemia revealed by p...