Clinical usefulness of determining C-reactive protein and fibrinogen concentrations and lipid profile in blood serum of patients undergoing surgery due to atherosclerosis
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2008, Vol 2, Issue 1
Abstract
Determination of basic blood biochemical parameters are used as a measure taken in atherosclerosis prophylaxis, or is performed depending on the complications found in the course of the disease. The aim of the study was to find diff erences between basic biochemical parameters measured in blood serum of patients with atherosclerosis. The study comprised 52 men, who were divided into three groups depending upon the type of surgical procedure performed due to atherosclerosis on internal carotid artery, aortic – iliac section and femoral – popliteal section of the femoral artery. The serum concentration of C-reactive protein was determined with the use of the rocket immunoelectrophoresis method (RI). The levels of total cholesterol, its HDL and LDL fractions and triglycerides were measured by the immunoenzymatic method (ELISA). Fibrinogen level was determined according to Clauss’s and ELISA tests. Total cholesterol, HDL and LDL fractions and triglycerides remained within the norm. Performed biochemical examinations did not significantly differ between the analysed groups of patients. Collective analysis of the correlation coefficient between the analysed parameters showed that the serum triglyceride concentration decreases with the patients’ age. An increase in the acute phase protein concentration was accompanied by a decrease in the concentrations of total cholesterol, LDL and triglycerides. The above relationship was not found in the case of HDL fraction of cholesterol. The results show that the biochemical determinations performed in blood serum of patients with atherosclerosis are not dependent on the location of an obliterated vessel. The significant parameters in this analysis are the acute phase protein concentration (CRP) and the fibrinogen level.
Authors and Affiliations
Piotr Niedziela, Andrzej Szczepanowski, Roman Paduch
Keywords
Related Articles
- EP ID EP58600
- DOI -
- Views 70
- Downloads 0
Clear cell renal carcinoma metastasis in the oral cavity – Case report
Introduction. Metastatic renal cell carcinoma can spread from the primary renal cell carcinoma to other organs, practically to all tissues. Distant metastases – to the tissue of the head and neck – are transferred throug...
Influence of irbesartan on the pharmacodynamics and pharmacokinetics of gliclazide in rats and rabbits
The influence of irbesartan on the hypoglycemic effect of gliclazide was studied in normal/diabetic rats and normal rabbits. Gliclazide and irbesartan was studied at a dose of 1.44 mg/200 g, 5.4 mg/200 g in normal/diabe...
ECG movement artefacts can be greatly reduced with the aid of a movement absorbing device
Accurate ECG signal analysis can be confounded by electric lead, and/or electrode movements varying in origin from, for example, hiccups, tremor or patient restlessness. ECG signals recorded using either a conventional e...
Paraneoplastic syndromes in daily clinical practice
Paraneoplastic syndromes consist of disorders that accompany benign and malignant tumours, but are not directly related to mass effects or invasion by the primary tumour or its metastases. The pathophysiology of mostly p...
Chronic fatigue syndrome after neuroborreliosis in farmers from Lublin region (Poland)
Chronic Fatigue Syndrome (CFS) is characterized by a chronic (lasting longer than 6 months) feeling of fatigue and a complex of other symptoms that include headache, muscle and joint aches, memory and concentration disor...