Helicobacter pylori and rheumatoid arthritis
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2007, Vol 1, Issue 1
Abstract
The aim of the research was to evaluate a possible relationship between [i]Helicobacter pylori (H. pylori)[/i] and rheumatoid arthritis. The presence of and sero-prevalence of IgG antibodies to [i]H. pylori[/i] were determined in 59 Danish rheumatoid-arthritis patients. The sero-prevalence was compared to the prevalence of controls and the background population. [i]H. pylori[/i] in infected and uninfected patients were compared with regards to clinical and demographic characteristics, and the extent of their inflammatory disease activity. [i]H. pylori[/i] was found in 18 patients (31%). The sero-prevalence of [i]H. pylori[/i] was 32%, non-significant to the prevalence of controls (36%), and of the background population (26%). [i]H. pylori[/i]/HLO positive and [i]H. pylori[/i]/HLO negative patients were similar with regards to clinical and demographic characteristics and inflammatory disease activity. Our results did not show an aetiologic relationship between [i]H. pylori[/i] and rheumatoid arthritis, but further studies are needed to discard the hypothesis completely.
Authors and Affiliations
Lykke B. Graff, Leif P. Andersen, Anne Gernow, Annie Bremmelgaard, Olaf Bonnevie, Stig Bondesen, Bente Danneskiold-Samsøe, Else M. Bartels
Keywords
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