Clinical Utility of GST and CEA in Gastrointestinal Cancer
Journal Title: International Journal of Innovative Research in Medical Science - Year 2017, Vol 2, Issue 7
Abstract
Purpose: - To analyze the level of serum Glutathione-S-Transferase (GST) and Carcinoembryonic antigen (CEA) before and after different Cycles Of chemotherapy in GI carcinoma patients. Methods: - For the study comprising total 58 cases suffering from GI carcinoma stage I, stage II stage III and Stage IV (before and after different cycle of chemotherapy) were selected. All patients were clinically and histologically diagnosed. A total of 42 age and sex matched healthy subjects taken as control. The circulating levels of GST and CEA activity were assayed in the in the serum of control group and in patients with GI carcinoma. Results: - Serum level of GST and CEA were highly significant in GI carcinoma patients as compared to control group (p<0.001). After first cycle of chemotherapy (stage II) the activity of GST and CEA were significantly higher than before chemotherapy (stage I). In stage III (after second cycle of chemotherapy) activity was significantly decreased than that of stage II and the activity of GST and CEA was significantly decreased in stage IV (after third cycle of chemotherapy) than stage III (after second cycle of chemotherapy). Conclusion:- On the basis of data from our study, it can be stated that serum GST measurement in plasma may be useful tumor marker in gastrointestinal carcinoma, its activity might helpful to predict the response of chemotherapy in advance stage of cancer. CEA is a tumor marker that is measured using a blood test.CEA tumor marker is one of the general type tumor markers. A multiply increased CEA levels in the blood indicate to the presence of a malignant disease in the body, but not to the organ in which the malignant change has occurred. High levels of CEA may indicate that cancer has spread; however, other medical conditions and some treatments, including certain types of chemotherapy, may raise CEA levels. CEA tests are one way doctors can find out whether the cancer has spread or returned. Cancer that has spread or returned can be treated successfully for many patients. CEA measurement is mainly used to identify recurrences after surgical resection and for staging.
Authors and Affiliations
Ranjit S. Ambad, Rajesh Bhanudas Rajekar, Nishikant Ingole
Keywords
Related Articles
- EP ID EP449381
- DOI -
- Views 78
- Downloads 0
"Nonalcoholic Fatty Liver and Metabolic Syndrome in a Population of Southeastern Mexico"
“NASH (Non-alcoholic steato hepatits) disease and metabolic syndrome in Mexico´s southeastern population Introduction: The nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease associ...
How Using Technology Enhanced Learning Could Help Modernise Traditional Large Group Teaching or Lecturing
The efficiency of lecturing or large group teaching has been called into question for many years. An abundance of literature details the components of effective teaching which are not provided in the traditional lecture...
Study of Brachial Plexus and Its Variations Including Roots, Trunks and Cords in Formalin Preserved Cadaveric Human Brachial Plexuses
Brachial plexus is a principal somatic nerve supplying upper limb. Variations involving brachial plexus are not uncommon and knowledge of same is important for anatomists, surgeons and radiologists.
Evaluation of Effectiveness of Boswellia Dalzielii Ethanol Bark Extract in the Control of Poultry Coccidiosis Experimentally Induced in Vom- Nigeria
In this study, the effectiveness of Boswellia dalzielli ethanol bark extract was evaluated experimentallywith Sulphachlopyrazine (ESB3™) in the treatment of cecal coccidiosis in broiler chickens in Vom. A total of 28 bir...
Multicentre Spectrum of Esophageal Motility Disorders in the Indian Subcontinent
Background - Motor disorders of the esophagus are rare and regional variations in their occurrence have not been studied in India. Aim and objectives - To study the spectrum of major and minor motor disorders in patient...