Clinical Utility of Serum Human Epidermal Growth Factor Receptor Type 2 Testing as a Marker of Therapeutic Response In Tissue HER2-Positive Breast Cancer Patients
Journal Title: International Journal of Cancer and Clinical Research - Year 2017, Vol 4, Issue 2
Abstract
Background Human Epidermal growth factor Receptor type 2 (HER2) is over expressed in 20.0-30.0% of breast cancers and is currently evaluated histopathologically. Immunohistochemistry and fluorescence in situ hybridization require invasive enucleation of the tumor tissue and may be affected by heterogeneity. Serum marker tests are more objective because of the uniformity of the study material. Serum HER2 levels are important for breast cancer care. However, the clinical utility of serum HER2 testing is unclear. We evaluated serum HER2 as a marker of therapeutic response in breast cancer. Methods Serum HER2 levels were measured in 64 tissue HER2-positive breast cancer patients during routine care. Relationships between serum HER2 levels, clinical stage, tumor diameter, therapeutic response, and Distant Metastasis (DM) were analyzed. Results Serum HER2 levels correlated with therapeutic response. An association was observed between serum HER2 levels and tumor diameter. Serum HER2 levels were significantly higher in patients with DM than in those without DM. Conclusions Serum HER2 levels are associated with therapeutic response, tumor diameter, and DM. We confirm the clinical utility of serum HER2 testing for monitoring therapeutic response and disease progression in patients with breast cancer.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP352243
- DOI 10.23937/2378-3419/1410089
- Views 138
- Downloads 0
Trastuzumab Emtansine in Patients with HER2-Positive Metastatic Breast Cancer: a Multicenter Japanese Retrospective Study
Introduction: Trastuzumab emtansine (T-DM1) is currently approved for the treatment of patients with HER2-positive metastatic breast cancer after failure of prior anti-HER2 therapies. However, the efficacy of T-DM1 in pa...
Acetylation of α-tubulin by a Histone Deacetylase Inhibitor, Resminostat, Leads Synergistic Antitumor Effect with Docetaxel in Non-Small Cell Lung Cancer Models
Background: There is a growing body of clinical evidence to demonstrate that inhibition of histone deacetylase is effective in the treatment of various types of cancer. We examined whether acetylation of a non-histone pr...
In Vitro Reaction of Cells Derived from Human Normal Lung Tissues to Carbon-Ion Beam Irradiation
Background: Radiation-induced lung injury (RILI) is a serious concern in carbon-ion radiation therapy (CIRT) for thoracic malignancies. To estimate the induction of RILI after CIRT, translation of evidence in X-ray radia...
The Role of Notch Signaling in Liver Diseases: Contribution to Development and Cancer
Liver tissue consists of several types of cells such as hepatocytes, endothelial cells, stellate cells, cholangiocytes, and immune cells, all with essential functions. The liver plays an important role in metabolism beca...
The Omission of Axillary Lymph Node Dissection in Sentinel Node-Positive Breast Cancer Patients Requires Careful Consideration
Sentinel Node Biopsy (SNB) is used to accurately assess axillary lymph node status in patients with node-negative breast cancer. The purpose of this study was to assess the association between Non-Sentinel Node (SN) meta...