The Role of Notch Signaling in Liver Diseases: Contribution to Development and Cancer
Journal Title: International Journal of Cancer and Clinical Research - Year 2017, Vol 4, Issue 1
Abstract
Liver tissue consists of several types of cells such as hepatocytes, endothelial cells, stellate cells, cholangiocytes, and immune cells, all with essential functions. The liver plays an important role in metabolism because its cells act on a variety of substances, transforming them into metabolic products essential for life and the production of waste products. One interaction between different adjacent cells is known as Notch signal transduction, and abnormalities in this signaling pathway can cause serious liver diseases including inherited diseases and cancer that sometimes exhibit aggressive phenotypes and have poor prognoses. Moreover, over activation of Notch signaling is associated with tumorigenesis and linked to the development of cancer stem cells. Here, we review the association between liver diseases and Notch signaling abnormalities related to signal transduction in the liver and the development of hepatocytes or cholangiocytes.
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- EP ID EP352226
- DOI 10.23937/2378-3419/1410079
- Views 125
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