Clinical Value of Human Leucocyte Antigen G (HLA-G) Expression in the Prognosis of Colorectal Cancer
Journal Title: International Journal of Cancer Management - Year 2017, Vol 10, Issue 4
Abstract
Objectives Overexpression of human leukocyte antigen G (HLA-G) in several malignant tumors has been reported. The aim of our study was to investigate HLA-G expression in colorectal cancer tumors and determine HLA-G expression relation between clinico-pathological characteristics and survival time. Methods HLA-G expression was evaluated by immunohistochemistry (IHC) using anti-HLA-G antibody in 100 primary tumors of colorectal cancer with different stages. Results Our results showed that 25% of the colorectal cancer tissues had positive HLA-G expression and 75% no stained with anti-HLA-G antibody. The HLA-G expression in advanced stages (III and IV) was more prevalent than those in earlier clinical stages (I and II) (P = 0.0001). Results showed that HLA-G expression can serve as an independent factor for overall survival (OS). In this study, patients with HLA-G expression had significantly shorter survival time than those with negative expressions (P = 0.023). Conclusions HLA-G expression can serve as an independent factor for OS and its expression may be directly related to aggressive tumor behavior via escape from the host antitumor immune defense. Protein expression of HLA-G correlates with poor prognosis in colorectal cancer.
Authors and Affiliations
Roghaieh Samadi, Ehsan Nazemalhosseini Mojarad, Mahsa Molaei, Faranak Kazerouni, Hamid Asadzadeh Aghdaei, Masoumeh Navidinia, Ali Rahimipour
Keywords
Related Articles
- EP ID EP237358
- DOI 10.5812/ijcm.9346
- Views 90
- Downloads 0
Frequency of Chemotherapy Induced Anemia in Breast Cancer Patients
Background: Breast cancer is the second mostcommonmalignancy in women, worldwide. Several etiologic factors may cause anemia in a patient with breast cancer. Anemia is a prevalent complication in patients with breast can...
Association between VDR Gene Polymorphisms (<i>rs 1544410</i>, <i>rs 7975232</i>, <i>rs 2228570</i>, <i>rs 731236</i> and <i>rs 11568820</i>) and Susceptibility to Breast Cancer in a Sample of Southeastern Iranian Population
Background Vitamin D receptor (VDR) is a key nuclear receptor that is associated with the risk and progression of breast cancer (BC). Objectives The present study investigated the...
No Association Between Human Papillomavirus and Prostate Cancer
Background: The role of human papillomavirus (HPV) in prostate cancer is unclear. The aim of this study was to investigate the relationship between HPV and prostate cancer. Methods: In this case - control study, 133 par...
Comparison of Surgical Margin After Breast Cancer Surgery Between Oncoplastic Technique and Conventional Breast-Conserving Surgery
Background: Compared to other breast surgery methods, the accurate determination of pathologic margin in oncoplastic technique can affect its development and further employment of this technique. The current study aimed...
The Role of Echocardiography in Detection of Chemotherapy-Induced Cardiotoxicity in Breast Cancer Patients
Context: The incidence of breast malignancy is increasing and it became evident that chemotherapy protocols that are based on anthracyclinesandtrastuzumab, which are being used in these patients, have cardiotoxic effect....