Clinicals, epidemiologicals and therapeutics features of patients with Acute Limphoblastic Leukemia in Hematology Clinic-Timişoara
Journal Title: Terapeutica, Farmacologie si Toxicologie Clinica - Year 2008, Vol 12, Issue 3
Abstract
Acute limphoblastic leukemia is a clonal neoplazic profileration of the progenitor limphoids stem cells characterized by their differentation stop and growth, the incidence of the disease being influenced by age, sex, ethnical, genetical factors, exposure to noxes. [b]Objectives:[/b] The study aims to evaluate the incidence of leukemia evaluation to certain factors (age, sex, occurring environment, personal habits, exposure to noxes, pathological personal and family history) and the overall survival rate in accordance with therapy, for a period of ten years with the help of a retrospective epidemiological descriptive study. [b]Material and method:[/b] The research was done in the Hematology Clinic Timişoara, started in 01.01.1996 and finished in 31.12.2005 – in the studied lot there were introduced newly diagnosticated patients in the clinic with acute limphoblastic leukemia. Evaluated factors were: age, sex, occurring environment, personal habits, exposure to noxes, pathological personal and family history, therapy, remission rate and the overall survival rate. [b]Conclusions:[/b] The incidence of the disease is greater in the years 2002, 2005, 1997, 1999; the greatest frequency being at the age group under 20 years old, a second peak of the frequency curve being observed at the age 40 to 50 years old, and the variation of the leukemia incidence as far as the month of birth was concerned being statistically insignificant. The predominance of the male sex was noticed, a greater frequency of the disease among the patients coming from the urban environment, a third of the patients being smokers, 19.29% of the patients are exposed to noxes, and 14.03% presenting pathological heterocolateral antecedents respectively personal pathological antecedents.
Authors and Affiliations
Violeta Teodorescu, M. Gafencu, Hortensia Ioniţă
Keywords
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