Clinico biochemical abnormalities in Thalassemia
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 21, Issue 1
Abstract
Problem statement: Thalassemias are a group of inherited disorders of Hb synthesis characterised by a reduced rate of production of one or more globin chains of Hb resulting in an anaemic state. Blood transfusion which both elevates the anaemia and suppresses the compensatory mechanism is the basis of therapy. But the inevitable consequence of prolonged transfusion therapy is the hemosiderosis. This causes complications like endocrine abnormalities along with hepatic and myocardial siderosis. The group with regular blood transfusion has the more chance of iron excess. The patients with inadequate transfusion are not free from the danger of iron overload because in them the anaemia causes excessive iron absorption. The endocrine glands are not also free from the burnt of hemosiderosis The excess iron in the storage form of ferritin get deposited in endocrine organs like pituitary, pancreas, parathyroid, and thyroid. Methods: It was performed on selected patients with diagnosis of Thalassemia disease, who were attending in both institution (Malda Medical College and M.G.M Medical College and L.S.K Hospital,)The 30 patients were included in our study. In the present study maximum number of cases were in the age group of 5-15 years (68%) and 32% of patients were in the age group of 16-25 years. Results: Dysfunction of the thyroid gland is less frequent than other endocrinopathies in thalassemia patients. Results are Distribution of Cases in Different Types of Thalassemia: Growth Hormone Study, Gonadotrophins Study. In our study no patient had yet developed hypothyroidism but possibilities of hypothyroidism in future specially of the sub-clinical hypothyroid patients remain.
Authors and Affiliations
Suman Ghosh, Sheereen Tarannum, Monidipa Ghosh
Keywords
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