Clinico-Epidemiological Profile of Elderly Patients with NonAlcoholic Fatty Liver Disease
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Introduction:Most patients of Non-alcoholic fatty liver disease (NAFLD) are in the age group of 40 to 50 years, which is also associated with more severe liver fibrosis and higher mortality. In this study we aim to understand the clinic-epidemiological profile of patients with NAFLD in Jalandhar district of Punjab. Methodology: We selected patients from randomly selected five hospitals in Jalandhar district, Punjab from January 2017 till June 2017. We included all consecutive patients, aged 60 years or above, with a diagnosis of NAFLD. We interviewed the patients using a pre-tested semi-structured questionnaire. Patient related information like demographics, lifestyle related risk factors, body mass index (BMI), alcohol and smoking habitswere collected. Furthermore, we collected information on various metabolic variables of the patients like fasting glucose, lipid profile and liver function test. Results:We enrolled 382 patients with confirmed diagnosis of NAFLD; males comprised of 63% of the total study population. 48% of the patients in our study had BMI between 25 and 30 kg/m2 , and 38% had BMI more than 30 kg/m2 . Majority of the patients in our study population were current alcoholics and smokers. 50% of the patients had fasting glucose higher than 110 mg/dL, 52% of the patients had triglycerides higher than 150 mg/dL and HDL levels higher than normal in 48% of the patients. Average aspartate transaminase reported was 17 U/L, average alanine transaminase was 22 U/L and average gamma-glutamyltransferase was 19 U/L. Conclusions: NAFLD may progress to fibrosis or cirrhosis in the older age group patients. Usually mild or moderate elevations in liver enzymes levels are seen, though normal enzyme levels do not exclude NAFLD.
Authors and Affiliations
Dr. Surinder Sharma,MD, Dr. Jagir Singh,MD
Keywords
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- EP ID EP244780
- DOI 10.9790/0853-1610133033
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