Gene therapy: Recent development, benefits and pitfall
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
Abstract: The use of gene therapy technology to treat genetic diseases has achieved great success in last few years. The advance in biotechnology field provides much hope for the future of gene therapy and made this method possible to treat and cure many genetic, infectious and chronic diseases. Furthermore the unavailability of proper treatment and cure for many diseases made gene therapy urgent need. Gene therapy has sparked great interest because it offers the possibility of a permanent cure. The recent discoveries in DNA technology like mi RNA and CRISPER/Cas9 simplify the difficulties and challenges in gene therapy like the gene vector and gene expression control. In addition, it is possible now to use gene therapy for germ-line correction. Gene therapy consists of the introduction of normal genetic material into cells with genetic abnormalities for a therapeutic purpose. A wide range of vectors have been developed and used for this biotechnology. The world predicting that in the next twenty years DNA technology and gene therapy will change the practice of medicine from a treatment-based to a prevention-based practice. Researchers are starting to move away from developing new drugs, and towards finding an ultimate solution. They hope that in the coming years, every genetic disease will have gene therapy as its treatment. Gene therapy could be the last therapy that the human race will ever need. Gene therapy has some potential risks. A gene can't easily be inserted directly into patient’s cells. The very expensive therapies have a lot of unknowns and raise a number of ethical and practicality questions. This manuscript reviews the potential use of the gene therapy as well some of the pitfalls and challenges.
Authors and Affiliations
Murtaza Mustafa, AF. Salih, EM. IIIzam, B. Almohtafar . , S. Hamed, MK. Nang, AM. Sharifa
Keywords
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