Clinico-etiological profile of the neonates with thrombocytopenia admitted to NICU in a rural hospital - A cross sectional study
Journal Title: Medpulse International Journal of Pathology - Year 2019, Vol 10, Issue 2
Abstract
Background: The most common haematological abnormality seen in neonates admitted to neonatal intensive care unit (NICU) is thrombocytopenia. Even though thrombocytopenia is more prevalent many a times it is not treated properly assuming that it will resolve by itself. If this finding is not detected and treated properly can result in serious complications. The present study was performed to determine the maternal and neonatal causes, time of onset and degree of thrombocytopenia.Materials and methods: A prospective observational study was conducted for a period of 1 year on neonates admitted to NICU with various causes. Blood samples from these neonates were collected and analysed for time of onset and severity of thrombocytopenia.Results:Out of 409 neonates admitted to NICU 264 developed thrombocytopenia with a prevalence of 65.5%. 65% had early onset thrombocytopenia and 35% had late onset thrombocytopenia. The most common neonatal cause was prematurity whereas most common maternal cause was pregnancy induced hypertension (PIH). Severe degree thrombocytopenia was found in 67.8 % in contrast to mild and moderate thrombocytopenia.Conclusion:Thrombocytopenia is the common finding seen in neonates with many causes. Significant association was found with prematurity, respiratory distress, sepsis and maternal hypertension. Hence platelet count can be used as a prognostic marker which can help in further diagnostic workup and management.
Authors and Affiliations
Shilpa M D, Chaithanya M
Keywords
Related Articles
- EP ID EP615158
- DOI 10.26611/1051027
- Views 70
- Downloads 0
Comparison of estrogen receptor, progesterone receptor and Ki-67 immunohistochemistry scoring using manual method and image analysis in breast carcinoma cases
Background: Breast carcinoma is the leading cause of carcinoma death in women. Estrogen receptors(ER), progesterone receptors(PR) and Ki-67 are important prognostic determinators. However immunohistochemistry (IHC) repor...
Role of S-100 immunostain as a diagnostic aid to demonstrate nerve changes in lepromatous leprosy and borderline lepromatous leprosy
Background: Leprosy is a chronic infectious disease, which has been targeted for eradication in India. To achieve complete elimination, it is necessary to achieve early and definitive diagnosis. A definitive diagnosis of...
Megakaryocyte changes in thrombocytopenia in bone marrow aspiration
Background: Megakaryocyte (MK) is one of the vital hematopoietic cell encountered in the bone marrow aspirate smears. MK has been studied extensively in the past and is known to show dysplastic changes in thrombocytopeni...
Validity of sickling test and peripheral blood film method for sickle cell disease screening in tertiary care hospital
Background: Sickle cell disease is one of the most common inherited monogenic disorders, accounting for about 70% of world’s major haemoglobinopathies. The sickle cell genes predominantly seen among the tribal population...
Onco-pathological correlation of hormonal receptors and HER2/neu expression in breast cancer
Background: Breast cancer is a complex genetic disease characterized by the accumulation of multiple molecular alterations. Hormone receptor studies such as estrogen receptor (ER), progesterone receptor (PR), and human e...