Clinico-Etiological Study of Efficacy of Autologous Platelet Rich Fibrin in Chronic Non Healing Ulcers.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Background: Chronic ulcers,often disguised as a comorbid condition, are presenting as a silent epidemic affecting a large fraction of the world population and posing as a major and gathering threat to the public health and economy. Autologous Platelet-rich fibrin (PRF) is one of the cost effective, easy, newer modalities for chronic ulcers and it contains fibroblast growth factor (FGF), vascular endothelial GF, angiopoietin and platelet-derived GF which enhances the wound healing. Aim: The aims of the present study are to determine the efficacy of autologous platelet-rich fibrin for nonhealing ulcers and to compare the rate of healing of different ulcers based on aetiology, taking care of the primary disease. Methods: A nonrandomized, uncontrolled study was performed on 30 patients with 30 non-healing ulcers of various aetiologies with healthy granulation tissue. Uncontrolled diabetics, seropositive individuals were excluded. All patients were treated with PRF at weekly intervals for a maximum of 6 treatments. Area and volume were calculated and photographs were taken. Final assessment of reduction in the size of the ulcer was determined in percentage . Results: The mean age of the patients observed was 43.3 years. Mean duration of healing observed was 4.5 weeks. The total Mean percentage improvement in the area and volume observed was 95.8%,100% respectively by 6thsitting. No significant statistical correlation is observed between the age of the patient, sex of the patient and site of the ulcer and aetiology of ulcer with the rate of healing of healing of the ulcer. All ulcers closed by a maximum of six sittings. No adverse events were noted Conclusion: In comparison to conventional dressings, autologous platelet rich fibrin provides necessary growth factors for wound healing and it is a safe, affordable, biocompatible, and simple procedure for the treatment of chronic non-healing ulcers
Authors and Affiliations
Dr. Gajjala Madhavi, Dr. I. Chandrasekhar Reddy, Dr. Y. Aruna kumari, Dr. B. Udaya Kumar
Keywords
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- EP ID EP467763
- DOI 10.9790/0853-1802155158.
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