Clinico-Functional Characteristics of Left Ventricular Dysfunction in Patients with Glomerulopathies and Their Relationship to Morphological Changes in The Kidneys
Journal Title: Journal of Urology & Nephrology Studies - Year 2018, Vol 1, Issue 1
Abstract
Purpose: To study the possible association of cardiac function with morphological changes of the kidneys in glomerulopathies. Materials and Methods: 55 patients with GP were examined (32 men, 23 women) aged from 17 to 58 (on the average 32.76 ± 10.3) years. Given the high prevalence left ventricular systolic diastolic dysfunction in patients with GP with impaired renal function, analyzed the data of patients with CKD stages 1-3. The mean GFR was 87.92 ± 28.2 ml / min / 1.73 m2. Histology, immunofluorescence and electron microscopic method of investigation were used in the study of nephrobiopsy data. Results: Analysis of the frequency of morphological types of nephropathy in the examined patients made it possible to detect the prevalence of membranous glomerulonephritis (MG), which accounted for 43.6% of observations. IgA nephropathy was detected in 36.4% of cases. Focal-segmental glomerulosclerosis and minimal-change disease were much less common and in an equal proportion (7.3% of cases). Less often (in 5,4%) was marked by membrane-proliferative glomerulonephritis. Damage to glomerulus and endothelial proliferation significantly influenced the delay in the flow of early diastolic filling of the left ventricle deceleration and isovolumic relaxation time. The Conclusion: The causes of the development of diastolic dysfunction of the heart are the damage of glomerulus, endothelial proliferation, deposits of the complement fraction C3 in GP.
Authors and Affiliations
Aiypova Dinara, Beishebaeva Nasira, Sarybaev Akpay, Kaliev Rysbaek
Keywords
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- EP ID EP604603
- DOI 10.32474/JUNS.2018.01.000105
- Views 50
- Downloads 0
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