Vasculitispauciimmun Following Silicone Exposure from Breast Implantation
Journal Title: Journal of Urology & Nephrology Studies - Year 2018, Vol 1, Issue 1
Abstract
We describe a case of a 35-year-old woman who developed renal vasculitis in the setting of exposure to silicone after breast implantation. Silicone implantation is associated with scleroderma, systemic lupus erythematosus, and rheumatoid arthritis. In 1964, Miyoshi first coined the term human adjuvant disease in their report of two patients who developed connective tissue-like disease after exposure to silicone-related substances during augmentation mammoplasty. Since this first observation, there have been numerouspublished cases relating silicone exposure to autoimmunerheumatic diseases. We, herein, report a patient who developed vasculitis and chronic renal failure after implantation of silicone mammoplasty. A 35 years old woman with a history of a right mastectomy in December 2014, for ductal carcinoma in situ with immediate breast reconstruction with silicone prosthesis. The assessment of extension is normal. She was hospitalized fifteen days after surgery for urinary infection with discovery of renal failure with a creatinine level of 500μmol/L; she was put under antibiotic treatment and is then output with a creatinine of 200mol/L. The patient was transferred to our department in late January 2015 for investigation of the renal failure (creatinine level 717μmol/l). Her physical examination was normal excluding significant edema of the lower members and normalarterial high blood pressure. Additional testing revealed microscopic hematuria, renal failure, elevated CRP and anaemia (Table 1).
Authors and Affiliations
Awatef Azzebi, Dorsaf Zallema, Wissal Sahtout, Narjes Ben Aicha, Yosra Guedri, Sanda Mrabet, Asma Fradi, Samira Ben Amor, Ferdaoues Sabri, Moncef Mokni, Abdellatif Achour
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- EP ID EP604576
- DOI 10.32474/JUNS.2018.01.000101
- Views 52
- Downloads 0
Vasculitispauciimmun Following Silicone Exposure from Breast Implantation
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