Clinico-Morphological Profile of Adrenal Tumors in Childhood
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 1
Abstract
The clinical manifestations and biologic behaviour of adrenal tumors in childhood can be quite distinct from their histologically similar counterparts in the adult population. We report 5 cases of adrenal neoplasms in young children and review their clinical presentations, endocrinological profile, pathology, and follow-up data. Pathologic evaluations included histology and immunostaining with NSE, synaptophysin and chromogranin. The patients included 3 girls and 2 boys, all <11 years of age. All the patients presented with hormone-related symptoms like Cushing syndrome for an average duration of 6 months. Serum testosterone levels were elevated in 2 cases. Imaging studies revealed neoplasms in the left adrenal gland in 2 cases and in the right adrenal gland in 3 cases. No evidence of disease was identified at any other site of the body. The tumors were grossly confined to the adrenal glands and ranged in size from 1.5 to 4.8 cm diameter. Microscopically, the tumors had histological and immunohistochemical features characteristic of adrenocortical tumors and neuroblastomas.
Authors and Affiliations
Pranati Pradhan, Pragyan Lisha Panda
Keywords
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- EP ID EP530057
- DOI 10.21276/ijmrp.2018.4.1.061
- Views 88
- Downloads 0
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