Clinico-pathological correlations of macular lesions in leprosy, using a new histological grading system
Journal Title: IP Indian Journal of Clinical and Experimental Dermatology - Year 2018, Vol 4, Issue 4
Abstract
In macular forms of paucibacillary PB leprosy as the dermal infiltrate is less greater precision in evaluation is needed both for diagnosis and for assessment of the efficacy of treatment With this in view a new numerical grading system on a scale from 04 with intervening decimals was recently published to describe each specific pathology of the dermal nerves and appendages This retrospective study of smear negative macular lesions has utilized this grading system for comparison and follow upFifteen new patients with PB macular leprosy TT BT were divided into two groups Group A without deformity ten patients and Group B with deformity five patients All the patients had pretreatment scalpel biopsies In the pretreatment biopsies in Group B the average grade of dermal granuloma was 13 compared to 05 in Group A Two patients in Group A who were given daily Rifampicin and Dapsone for five and six months respectively showed marked reduction in the infiltrate In many biopsies a linear serpiginous infiltrate horizontal was present in the superficial dermisThis new grading system is useful for quantifying the dermal pathology in PB macular leprosy for comparison of duration of treatment or evaluation of newer drugs in studies and for assessing resolution of the lesion by the pathologistKeywords Macular leprosy PB Histological grading Dermal granuloma Neural infiltrate and destruction Linear serpiginous infiltrate
Authors and Affiliations
Mohan Z. Mani
Keywords
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- EP ID EP488915
- DOI 10.18231/2581-4729.2018.0059
- Views 98
- Downloads 0
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