Clinico-Pathological Profile of NAFLD in Type 2 Diabetes Mellitus
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 10
Abstract
Non Alcoholic Fatty Liver Disease (NAFLD) is a spectrum of disorders seen in people without consumption of alcohol in amounts known to be toxic to the liver and characterized by pathological appearance of predominant macro-vesicular hepatic steatosis. Non-Alcoholic Steato-Hepatitis (NASH) is a metabolic liver disease in which fatty change i.e steatosis is accompanied with lobular inflammation, hepatocyte injury and/or hepatic fibrosis. NASH can be defined pathologically as significant steatohepatitis not resulting from alcohol, drugs, toxins, infectious agents or other identifiable exogenous causes. Abnormal liver function tests secondary to NASH/NAFLD has become the most common liver disease worldwide. This study was planned to evaluate the clinical and biochemical profile of 85 diabetic -out-patients and inpatients attending, the Department of Medicine, Government T.D.Medical College, Alappuzha. The study concluded that NASH prevalence is strongly associated with Female gender, hypertension, dyslipidemia and family history. Further, the occurrence of NASH was higher in those with longer duration of Type 2 Diabetes, uncontrolled Diabetes, higher waist-hip ratio and higher BMI. Presence of combination of low serum albumin levels, low-normal platelet counts, acanthosis nigricans and non-tender hepatomegaly was found to be a strongly predictive of NASH in diabetics.
Authors and Affiliations
Dr Rashmi KP.
Keywords
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