Clinicoetiological Profile of Patients Presenting With Drug Induced Liver Injury
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 7
Abstract
Introduction: Drug-induced liver injury (DILI) is common worldwide and has a potentially fatal outcome. We present here the clinical characteristics and outcome of patients with drug induced liver injury from our hospital. Materials and methods: we retrospectively looked at 25 cases of DILI who presented to our hospital in whom there was a causal or highly probable relationship between drug use and liver disease. Data was collected from MRD section of hospital. Results: The mean age of patients was 36 years; sexual distribution was 14 females and 11 males. The major cause of hepatotoxicity was drugs (88%), with herbal medicine accounting for 12%. The leading causative agents were Anti tubercular drugs (44%), followed by acetaminophen (20%). The pattern of hepatotoxicity was hepatocellular in 17 patients (68%), mixed in 4 (16%), and cholestatic in 4 patients (16%).Acute liver failure developed in 5 patients (two patients related to ATT, two related to acetaminophen and one patient due to Herbs). Conclusion: ATT and acetaminophen were the most common etiologic agents for drug-induced liver injury.
Authors and Affiliations
Dr. Aamir Malik
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