Clinicopathological analysis of nephrectomy cases
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 2
Abstract
Background: A retrospective and prospective study carried out from 2009 to 2016 which includes 57 cases Objectives: To analyse neoplastic and non-neoplastic causes of nephrectomy and correlate histopathological findings with clinical diagnosis and radiological findings. Methods: H and E stained sections of all nephrectomy specimens were studied. Special stains were performed when required. Results: Out of 57 cases, 39 (68%) were non-neoplastic and 18 ( 32%) were neoplastic. Chronic pyelonephritis was the commonest non-neoplastic cause comprising 32 (82%) cases, of which 73% cases showed obstructive uropathy. Of the 18 neoplastic cases, 2 were benign (renal papillary adenomas) and 16 were malignant. Most common malignant tumour in adults was Clear cell RCC accounting to 6 (75%) cases. All 7 (39%) cases in the paediatric age group were malignant, 3 of Wilms tumour (commonest), 2 of CCSK, 1 of Mesoblastic nephroma and 1 case of Rhabdoid tumour. All 57 cases correlated with clinical diagnosis and radiological findings. One case of rare dual tumours (Clear cell sarcoma [CCSK] and extra adrenal differentiating neuroblastoma was encountered. Conclusion: Histopathological examination helps in confirmation of neoplastic and non-neoplastic renal lesions. Male to female preponderance was 2.3:1. Most commonly involved age group was 1-10 years followed by 51-60 years. Most common presenting symptom was pain in abdomen. Most common lesion was chronic pyelonephritis. Malignant tumours were more common than benign. Most common benign lesion was papillary adenoma while most common malignant tumour was RCC in adults and Wilms tumour in children. Out of 57 cases, 22 cases underwent DTPA scan and showed 100% correlation with histopathology.
Authors and Affiliations
Priyam Pargaonkar, Manjiri Karandikar, N S Mani
Keywords
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