Clinicopathological Evaluation of Uterine Sarcomas: An Institutional Experience
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 5
Abstract
Introduction: Uterine sarcomas are highly malignant tumors accounting for 3-7% of all uterine malignancies. According to the World Health Organization, uterine sarcomas consist of two main categories: mesenchymal tumours and mixed tumours. Aims: To study the clinical presentation and analyze the spectrum of gross and microscopic features of uterine sarcomas. Methods: The present retrospective study was conducted in the department of pathology of a medical college teaching hospital from 2011 to 2016. Total number of hysterectomies were 1837, of which leiomyomas accounted for 70% and uterine sarcomas accounted for 0.6% (11 cases). Haematoxylin and Eosin stained slides of 11 cases of all uterine sarcomas were retrieved from the histopathology archives.Clinical features were taken from medical records and all H and E stained slides studied. Statistical Analysis: Continuous data was summarised using descriptive statistics. Qualitative variables were summarized using frequency and percentage Results: We report a series of 11 cases with mean age of presentation being 44.8 years. In majority of cases the clinical presentation was abdominal pain and vaginal bleeding and the commonest clinical diagnosis was fibroid uterus followed by endometrial carcinoma. Out of 11 cases, 6 cases were of endometrial stromal sarcoma, 2 carcinosarcoma and one case each of leiomyosarcoma, adenosarcoma and undifferentiated sarcoma. The stage of the tumors was predominantly stage I (72.7%) followed by stage IV (18.1%) and stage II (9%). Conclusion: Uterine sarcomas are rare malignant tumor. The diagnosis is difficult due to varied pathological differentiation and can be aided by immunohistochemistry.
Authors and Affiliations
Tarannum Fathima
Keywords
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- EP ID EP522604
- DOI 10.21088/ijprp.2278.148X.7518.8
- Views 82
- Downloads 0
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