Clinicopathological Evaluation of Uterine Sarcomas: An Institutional Experience
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 5
Abstract
Introduction: Uterine sarcomas are highly malignant tumors accounting for 3-7% of all uterine malignancies. According to the World Health Organization, uterine sarcomas consist of two main categories: mesenchymal tumours and mixed tumours. Aims: To study the clinical presentation and analyze the spectrum of gross and microscopic features of uterine sarcomas. Methods: The present retrospective study was conducted in the department of pathology of a medical college teaching hospital from 2011 to 2016. Total number of hysterectomies were 1837, of which leiomyomas accounted for 70% and uterine sarcomas accounted for 0.6% (11 cases). Haematoxylin and Eosin stained slides of 11 cases of all uterine sarcomas were retrieved from the histopathology archives.Clinical features were taken from medical records and all H and E stained slides studied. Statistical Analysis: Continuous data was summarised using descriptive statistics. Qualitative variables were summarized using frequency and percentage Results: We report a series of 11 cases with mean age of presentation being 44.8 years. In majority of cases the clinical presentation was abdominal pain and vaginal bleeding and the commonest clinical diagnosis was fibroid uterus followed by endometrial carcinoma. Out of 11 cases, 6 cases were of endometrial stromal sarcoma, 2 carcinosarcoma and one case each of leiomyosarcoma, adenosarcoma and undifferentiated sarcoma. The stage of the tumors was predominantly stage I (72.7%) followed by stage IV (18.1%) and stage II (9%). Conclusion: Uterine sarcomas are rare malignant tumor. The diagnosis is difficult due to varied pathological differentiation and can be aided by immunohistochemistry.
Authors and Affiliations
Tarannum Fathima
Keywords
Related Articles
- EP ID EP522604
- DOI 10.21088/ijprp.2278.148X.7518.8
- Views 84
- Downloads 0
Bilateral Proptosis: An Atypical Presentation of Acute Myeloid Leukaemia
Acute myeloid leukaemia accounts for nearly 15% of all leukaemias in children out of which only about 3% mases present with extramedullary deposits in the other sites like the orbit. Bilateral proptosis is fairly common...
Spectrum of Histopathological Patterns of Thyroid Lesions: A 2 Year Retrospective Study
Introduction: Thyroid is a readily palpable gland in the anterior inferior neck. Thyroid pathologies are common worldwide and are commonly encountered in clinical practice. Diseases of the thyroid are of great importance...
Is Cervical Cancer Incidence Decreasing in the Urban Population of India with Developing Healthcare, Socio Demographic Progress and Awareness Programmes?
Context: Last few decades saw rapid decline of cervical cancer worldwide. However, 75% of the new cases are reported to occur in developing countries due lack of awareness among the female population. Aims: This study w...
Histomorphological Study of Ovarian Tumors : A Three Year Institutional Experience
Context: Ovary contains four major types of tissue (Surface epithelium, Germ cells, Sex cords and Ovarian stroma), all of which can give rise to a variety of neoplasms, often combined with a varied morphological and hist...
Glycated Hemoglobin [HbA1C] As a Dual Marker for Glycemic Status and Dyslipidemia in Diabetics: A Cross Sectional Analysis of 450 Cases
Background: The prevalence of dyslipidemia in diabetes mellitus [DM] is 95%. Diabetic patients with accompanied dyslipidemia are soft targets of cardiovascular deaths. Glycated Hemoglobin [HbA1C] the gold standard for as...