Clinicopathological study of splenomegaly in pediatric age group
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 21, Issue 1
Abstract
The study is based on 100 cases in pediatric age group with splenomegaly carried out in the Government Medical College and Hospital, Aurangabad. The study group showed slight male predominance. Clinical grading of splenomegaly was done with conventional method. Majority of cases (87%) had either Grade I or II splenomegaly. Hackett’s method for grading of splenomegaly was also employed. Majority of cases (70%) had Grade I or II splenomegaly. The most common presenting complaint was fever followed by pallor. The other complaints were lump in abdomen, history of bleeding, pain in abdomen and symptoms of general ill health. The associated clinical findings were hepatomegaly (85%) and lymphadenopathy (33%). Hematological evaluation including bone marrow examination revealed diagnosis in the majority of cases (62%). These tests are safe, easy to perform and cost effective investigations. Other investigations like histopathology, biochemistry, serology, radiology proved helpful in the diagnosis in 16% cases. Anemia including hemolytic anemia and hematological malignancies were the common etiologies (28%) in the causation of splenomegaly. The Grade I and Grade II splenomegaly was the most common. Hemolytic anemia was the most common anemia (53.6%) followed by megaloblastic anemia (21.4%). The hematological malignancies also encountered frequently (28%). The most common malignancy was acute lymphoblastic leukemia (46.4%) followed by chronic myeloid leukemia (17.8%). The infectious etiologies included malaria, hepatitis, dengue fever, enteric fever etc. Malaria was the most common among them (46.1%). Infiltrative diseases mainly encountered in Grade III (conventional) and Grade 5 (Hackett’s method) splenomegaly.
Authors and Affiliations
Shubhajyoti N Pore, Sunita P Patil, Bindu Rajan S
Keywords
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